Brain Functional Network Generation Using Distribution-Regularized Adversarial Graph Autoencoder with Transformer for Dementia Diagnosis.

The topological connectivity information derived from the brain functional network can bring new insights for diagnosing and analyzing dementia disorders. The brain functional network is suitable to bridge the correlation between abnormal connectivities and dementia disorders. However, it is challenging to access considerable amounts of brain functional network data, which hinders the widespread application of data-driven models in dementia diagnosis. In this study, a novel distribution-regularized adversarial graph auto-Encoder (DAGAE) with transformer is proposed to generate new fake brain functional networks to augment the brain functional network dataset, improving the dementia diagnosis accuracy of data-driven models. Specifically, the label distribution is estimated to regularize the latent space learned by the graph encoder, which can make the learning process stable and the learned representation robust. Also, the transformer generator is devised to map the node representations into node-to-node connections by exploring the long-term dependence of highly-correlated distant brain regions. The typical topological properties and discriminative features can be preserved entirely. Furthermore, the generated brain functional networks improve the prediction performance using different classifiers, which can be applied to analyze other cognitive diseases. Attempts on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset demonstrate that the proposed model can generate good brain functional networks. The classification results show adding generated data can achieve the best accuracy value of 85.33%, sensitivity value of 84.00%, specificity value of 86.67%. The proposed model also achieves superior performance compared with other related augmented models. Overall, the proposed model effectively improves cognitive disease diagnosis by generating diverse brain functional networks.