AI Article Synopsis
- Partial heart transplants in pediatric patients involve replacing defective heart valves with parts from matched donor hearts, showing promising short-term outcomes but unknown long-term effects.
- A study evaluated 15 children who underwent heart transplants between 1997 and 2014, focusing on the growth and function of semilunar heart valves over a 10-year period, using echocardiograms for detailed analysis.
- Results indicated significant growth in both aortic and pulmonary valve sizes and maintained excellent function, suggesting that semilunar heart valves in infant transplants are likely to perform well over the long term.
Article Abstract
Introduction: Partial heart transplants are a new type of pediatric transplant that replace defective heart valves with the parts of matched donor hearts containing the necessary valves. Short-term outcomes of partial heart transplants are excellent, but long-term outcomes are unknown. In order to predict the long-term outcomes of partial heart transplants, we evaluated long-term growth and function of semilunar heart valves transplanted in infancy as part of a heart transplant.
Methods: All children who underwent infant heart transplantation at a single center from 1997 to 2014 were included in this study. Children in whom echocardiograms after heart transplantation and after 10 years were not available for review were excluded. The echocardiograms were reviewed by two authors to analyze semilunar valve annulus diameters, Z-scores, peak valve gradients, and valve regurgitation. Statistical difference was determined using two-tailed, paired sample t-tests with Bonferroni correction for multiple comparisons.
Results: Data from 15 patients were analyzed. The aortic valve annulus averaged 1.3 cm (range 0.7-1.8 cm) immediately after transplantation and grew to an average of 1.7 cm (range 1.4-2.3 cm) after 10 years (p < .001). After 10 years, the aortic valve peak gradient avereraged 5.1 mmHg (range 2.1-15.5 mmHg) and none of the valves had more than trivial regurgitation. The pulmonary valve annulus averaged 1.5 cm (range 1.1-2.5 cm) immediately after transplantation and grew to an average of 2.1 cm (range 1.0-2.9 cm) after 10 years (p < .001). After 10 years, the pulmonary valve peak gradient averaged 4.3 mmHg (range 1.1-13.8 mmHg), and 7% of valves had moderate regurgitation.
Discussion: Semilunar heart valves transplanted in infancy as part of a heart transplant demonstrate statistically significant growth and excellent function after 10 years. This predicts excellent long-term outcomes of partial heart transplants.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997160 | PMC |
| http://dx.doi.org/10.1111/petr.14746 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comprehensive Review of Phthalate Exposure: Health Implications, Biomarker Detection and Regulatory Standards.
J Steroid Biochem Mol Biol
December 2024
Department of Applied Chemistry and Chemical Engineering, Islamic University, Kushtia-7003, Bangladesh; Institute of Glass and Ceramic Research and Testing(IGCRT), Bangladesh Council of Scientific and Industrial Research(BCSIR), Dhaka-1205, Bangladesh.
Phthalates are a wide family of chemicals that are used in many different industrial applications used in many different industrial applications, including the production of plastics, toys, food packaging particularly for kids, and medical equipment. Due to their various chemical and physical properties, phthalates may negatively impact humans, animals, and the environment. Thus the potential for phthalate exposure and harm to humans, animals, and the environment is high because its presence is alarming.
View Article and Find Full Text PDFPartial replacement of the tricuspid valve using cryopreserved tricuspid homograft: 20-year outcomes.
Interdiscip Cardiovasc Thorac Surg
January 2025
Division of Cardiothoracic Surgery, Heart and Lung Institute, The Prince Charles Hospital, Brisbane, Australia.
Objectives: There is limited consensus on the optimal strategy for surgical treatment of severe tricuspid valve pathology. At our institution, we have implemented a unique technique of using a tricuspid homograft with its supporting apparatus for partial replacement of the native tricuspid valve. We now present the long-term outcomes of these patients.
View Article and Find Full Text PDFArtifacts at Cardiac MRI: Imaging Appearances and Solutions.
Radiographics
January 2025
From the Department of Radiology, Cardiovascular Imaging, Mayo Clinic, 200 1st St SW, Rochester, MN 559905 (P.S.R., P.A.A.); Department of Radiology, Division of Cardiothoracic Imaging, Jefferson University Hospitals, Philadelphia, Pa (B.S.); Department of Radiology, Baylor Health System, Dallas, Tex (P.R.); Department of Diagnostic Radiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR (M.Y.N.); and Department of Diagnostic Radiology, Cleveland Clinic, Cleveland, Ohio (M.A.B.).
Cardiac MRI (CMR) is an important imaging modality in the evaluation of cardiovascular diseases. CMR image acquisition is technically challenging, which in some circumstances is associated with artifacts, both general as well as sequence specific. Recognizing imaging artifacts, understanding their causes, and applying effective approaches for artifact mitigation are critical for successful CMR.
View Article and Find Full Text PDFAssociations between cardiac rehabilitation structure and processes and dietary habits after myocardial infarction: a nationwide registry study.
Eur J Cardiovasc Nurs
January 2025
Department of Clinical Sciences Malmö, Lund University, Box 117, 221 00 Lund, Malmö, Sweden.
Aims: Improved dietary habits are important for successful secondary prevention after myocardial infarction (MI), with counselling and support on healthy dietary habits constituting a cornerstone of cardiac rehabilitation (CR). However, there is limited knowledge on how to optimize CR organization to motivate patients to adopt healthy dietary habits. We aimed to explore associations between CR programme structure, processes, and self-reported dietary habits 1 year post-MI.
View Article and Find Full Text PDFPsychometric validation of the Cardiac Distress Inventory - Short Form among people with cardiac diseases in Hong Kong.
Front Psychiatry
December 2024
Centre on Behavioral Health, The University of Hong Kong, Hong Kong SAR, China.
Objectives: Cardiac patients experience various somatic and psychosocial symptoms and stress is an important prognostic factor of cardiac rehabilitation. This study evaluated the psychometric properties of the 12-item Cardiac Distress Inventory - Short Form (CDI-SF) in the Chinese context.
Methods: A total of 227 patients with cardiac diseases were recruited in a specialist outpatient clinic in Hong Kong between Aug 2022 and July 2023.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!