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| http://dx.doi.org/10.1186/s13058-024-01811-y | DOI Listing |
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Targeting Mitotic Exit in Malignant Cells.
Methods Mol Biol
November 2024
Faculty of Medicine, Department of Medicine I, Medical Center, University of Freiburg, Freiburg, Germany.
In order to sustain genomic stability by correct DNA replication and mitosis and thus avoid malignant transformation of cells, the cell cycle is a strictly regulated process. Aberrant cell cycle regulation and defects in mitosis in malignant cells are targets of various cancer therapies. Cancer cells may survive antimitotic treatment due to mitotic slippage with a residual activity of the ubiquitin ligase anaphase-promoting complex (APC/C) and a continuous slow ubiquitin-proteasome-dependent cyclin B-degradation leading to mitotic exit.
View Article and Find Full Text PDFSRPK Inhibitors Reduce the Phosphorylation and Translocation of SR Protein Splicing Factors, thereby Correcting , and Splicing Errors and Enabling Apoptosis of Cholangiocarcinoma Cells.
Front Biosci (Schol Ed)
September 2024
Department of Biochemistry, Faculty of Medical Science, Naresuan University, 65000 Phitsanulok, Thailand.
Article Synopsis
- Cholangiocarcinoma (CCA) is a bile duct cancer prevalent in Thailand, characterized by poor prognosis and low survival rates due to challenges in early detection and treatment.
- The study explores the role of serine/arginine protein kinases (SRPKs) in CCA, specifically how their hyperphosphorylation affects splicing factors linked to cancer-related mRNA errors.
- Results indicate that high levels of SRPK1 correlate with shorter patient survival and that SRPK inhibitors increase cell death in CCA cell lines, revealing potential targets for new treatments.
Comparison of AirAngel® vs. Storz® videolaryngoscope and Macintosh® laryngoscope for endotracheal intubation training: prospective randomized crossover study.
BMC Med Educ
August 2024
School of Medicine, Emergency Department, Acibadem Mehmet Ali Aydinlar University, Istanbul, 34457, Turkey.
Article Synopsis
- Video laryngoscopy (VL) is often more effective for airway management, but its high costs limit its use in low-income countries, making 3D-printed alternatives a potential solution.
- A study involving 126 inexperienced medical students tested the effectiveness of 3D-printed VL against conventional VL and Macintosh laryngoscope, measuring factors like intubation time and glottic visualization.
- Results showed that 3D-printed VL and conventional VL had similar performance, being faster and easier to use than the Macintosh laryngoscope, which had longer intubation times and lower glottic viewing scores.
Correction to: MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignancies.
Cell Death Dis
July 2024
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Correction: Cyclin E/Cdk2-dependent phosphorylation of Mcl-1 determines its stability and cellular sensitivity to BH3 mimetics.
Oncotarget
July 2024
Department of Immunology, Lerner Research Institute, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
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