Trehalases (TREs) are pivotal enzymes involved in insect development and reproduction, making them prime targets for pest control. We investigated the inhibitory effect of three thiazolidinones with piperine skeletons (6a, 7b, and 7e) on TRE activity and assessed their impact on the growth and development of the fall armyworm (FAW), . The compounds were injected into FAW larvae, while the control group was treated with 2% DMSO solvent. All three compounds effectively inhibited TRE activity, resulting in a significant extension of the pupal development stage. Moreover, the treated larvae exhibited significantly decreased survival rates and a higher incidence of abnormal phenotypes related to growth and development compared to the control group. These results suggest that these TRE inhibitors affect the molting of larvae by regulating the chitin metabolism pathway, ultimately reducing their survival rates. Consequently, these compounds hold potential as environmentally friendly insecticides.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jafc.3c08898 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Regulation of three novel pepper thiothiazolidinones on the fecundity of Spodoptera frugiperda.
Pestic Biochem Physiol
September 2024
Key Laboratory of Surveillance and Management of Invasive Alien Species, Guizhou Education Department, Department of Biology and Engineering of Environment, Guiyang University, Guiyang, China. Electronic address:
Spodoptera frugiperda has emerged as a major invasive pest worldwide. The utilization of chemical pesticides not only poses numerous ecological concerns but also fosters resistance in S. frugiperda.
View Article and Find Full Text PDFImpact of Three Thiazolidinone Compounds with Piperine Skeletons on Trehalase Activity and Development of Larvae.
J Agric Food Chem
April 2024
Key Laboratory of Surveillance and Management of Invasive Alien Species, Guizhou Education Department, Department of Biology and Engineering of Environment, Guiyang University, Guiyang 550005, China.
Trehalases (TREs) are pivotal enzymes involved in insect development and reproduction, making them prime targets for pest control. We investigated the inhibitory effect of three thiazolidinones with piperine skeletons (6a, 7b, and 7e) on TRE activity and assessed their impact on the growth and development of the fall armyworm (FAW), . The compounds were injected into FAW larvae, while the control group was treated with 2% DMSO solvent.
View Article and Find Full Text PDFThe mechanism by which Naru 3 pill protects against intervertebral disc cartilage endplate degeneration based on network pharmacology and experimental verification.
J Orthop Surg Res
July 2023
Peking University Cancer Hospital (Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University, NO.42 Zhaowuda Road, Hohhot, 010010, Inner Mongolia, China.
Context: Naru 3 pill is a traditional Mongolian medicine for the treatment of intervertebral disc degeneration (IDD), but the mechanism is not yet clear.
Objective: This study investigated the mechanism of Naru 3 pill in the treatment of IDD.
Materials And Methods: Active ingredients and related targets of Naru 3 pill, as well as IDD-related genes, were collected from public databases.
A Piperine-Based Scaffold as a Novel Starting Point to Develop Inhibitors against the Potent Molecular Target ChtI.
J Agric Food Chem
July 2021
State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection and Shenzhen Agricultural Genome Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100193, People's Republic of China.
Article Synopsis
- The insect enzyme ChtI from the Asian corn borer is crucial for its molting process and is a potential target for developing eco-friendly insecticides.
- A natural compound called piperine, found in black pepper, was identified for the first time as an inhibitor of ChtI, with its interaction occurring at a specific site on the enzyme.
- Researchers designed new compounds based on piperine that showed significantly stronger inhibitory effects on ChtI and moderate insecticidal activity, suggesting a promising pathway for green insecticide development.
Piperine mediates LPS induced inflammatory and catabolic effects in rat intervertebral disc.
Int J Clin Exp Pathol
May 2016
Shanghai Key Laboratory of Orthopaedic Implants, Department of Orthopaedics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Road, Shanghai 200011, China.
Piperine is an exact of the active phenolic component from Black pepper. It has been reported to have many biological activities including anti-oxidant, anti-inflammatory and anti-tumor effects. Intervertebral disc degeneration (IDD) is a degenerative disease closely relate to inflammation of nucleus pulposus (NP) cells.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!