AI Article Synopsis
- Recent studies show astrocytes play a key role in neuroinflammatory diseases like multiple sclerosis (MS), interacting with both CNS components and immune cells.
- Due to challenges in obtaining human astrocytes, their specific role in MS is not fully understood, prompting the development of an in vitro model in this study.
- Findings indicate that when treated with CSF from MS patients, astrocytes exhibit reduced pro-inflammatory markers while increasing neuroprotective growth factors, suggesting they help mitigate inflammation in MS.
Article Abstract
Recent studies highlighted the role of astrocytes in neuroinflammatory diseases, particularly multiple sclerosis, interacting closely with other CNS components but also with the immune cells. However, due to the difficulty in obtaining human astrocytes, their role in these pathologies is still unclear. In this study we develop an astrocyte in vitro model to evaluate their role in multiple sclerosis after being treated with CSF isolated from both healthy and MS diagnosed patients. Gene expression and ELISA assays reveal that several pro-inflammatory markers IL-1β, TNF-α and IL-6, were significantly downregulated in astrocytes treated with MS-CSF. In contrast, neurotrophic survival, and growth factors, and GFAP, BDNF, GDNF and VEGF, were markedly elevated upon the same treatment. In summary, this study supports the notion of the astrocyte involvement in MS. The results reveal the neuroprotective role of astrocyte in MS pathogenicity by suppressing excessive inflammation and increasing the expression of tropic factors.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987000 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0300203 | PLOS |
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