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Identifying and Understanding Seizure Liability in Drug Development.
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Allucent, Cary, NC, USA.
Seizures are complex electrophysiological disturbances affecting one or more populations of brain neurons. Seizures following test article (TA) exposure pose significant challenges in drug development. This paper considers the diverse neurological manifestations, mechanisms, and functional and structural assessments needed to investigate TA-related seizure liabilities, with a particular focus on nonclinical species.
View Article and Find Full Text PDFThe Complex Relationship Between Cannabis Use and Mental Health: Considering the Influence of Cannabis Use Patterns and Individual Factors.
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The relationship between cannabis use and mental health is complex, as studies often report seemingly contradictory findings regarding whether cannabis use results in more positive or negative treatment outcomes. With an increasing number of individuals using cannabis for both recreational (i.e.
View Article and Find Full Text PDFComparison of United States and Australian pharmacy student attitudes towards careers in geriatrics.
Curr Pharm Teach Learn
December 2024
Division of Practice Advancement and Clinical Education, Clinical Education, UNC Eshelman School of Pharmacy, 121 Karpen Hall, 1 University Heights, Asheville, NC 28804, United States; UNC School of Medicine and UNC Health Sciences at MAHEC, 123 Hendersonville Rd, Asheville, NC 28803, United States; Center for Healthy Aging, Mountain Area Health Education Center, 123 Hendersonville Rd, Asheville, NC 28803, United States. Electronic address:
Introduction: The population of older adults is expanding globally, but there remains a lack of healthcare professionals trained to meet growing care needs. The primary objective of this study was to compare the top three to four factors driving interest vs. lack of interest in geriatrics among pharmacy students in the United States (US) vs.
View Article and Find Full Text PDFEpidemiology of Low Back Injuries in National Collegiate Athletic Association (NCAA) Athletes: Results From the NCAA Injury Surveillance Program Between 2009-10 and 2018-19.
Am J Sports Med
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Datalys Center for Sports Injury Research and Prevention, Indianapolis, Indiana, USA.
Article Synopsis
- Regular investigations into low back injuries (LBIs) in NCAA sports are essential for understanding their causes and improving prevention and rehabilitation efforts.
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Characterizing the therapeutical use of ketamine for adolescent rats of both sexes: Antidepressant-like efficacy and safety profile.
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December 2024
IUNICS, University of the Balearic Islands, Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain; Department of Medicine, University of the Balearic Islands, Palma, Spain. Electronic address:
While ketamine was approved for treatment-resistant depression in adult patients, its efficacy and safety profile for adolescence still requires further characterization. In this context, prior preclinical studies have shown that sub-anesthetic doses of ketamine during adolescence exert antidepressant-like effects in rodents in a dose- and sex-dependent manner. However, additional studies evaluating the short- and long-term safety profile of ketamine at the doses necessary to induce antidepressant-like effects are needed.
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