AI Article Synopsis
- The study looks at how the edges of tumors in patients with a type of throat cancer (LSCC) treated with specific surgery (TOLMS) affect their chances of surviving.
- Researchers reviewed several previous studies to find out how having "positive" (cancerous) or "close" (very near) edges on the tumor might change survival rates.
- They found that more information is needed to understand the true impact of those edges on survival since the results were not clear and not enough studies provided good data.
Article Abstract
Purpose: In laryngeal squamous cell carcinoma (LSCC) treated with transoral laser microsurgery (TOLMS), the status of margins significantly affected local control. When a positive or close margin is present, there is no ubiquitous consensus regarding further treatments. The rationale of the present systematic review and meta-analysis is to investigate the survival impact of the status of the margins in patients affected by LSCC treated with TOLMS.
Data Sources: PubMed, EMBASE, and Cochrane Library.
Methods: We performed a systematic search, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Inclusion criteria were: patients affected by LSCC, staged according to the American Joint Committee on Cancer Staging System and treated by TOLMS without any previous treatment; margins status (close, positive, negative) and the adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) of overall survival, disease-specific survival, and disease-free survival has to be reported.
Results: Nine studies were deemed eligible for the qualitative analysis, and 3 for the quantitative analysis to investigate the association between margin status and OS. The cumulative number of patients was 3130. The sample size ranged from 96 to 747 patients. The follow-up period ranged from 0 to 201 months. The meta-analysis results show that positive margins have an aHR of 1.30 yet with CI range (0.56 to 2.97).
Conclusions: Our current meta-analysis results are unable to definitively assess the real impact of resection margins on OS. Few authors provide accurate data regarding position and types of margins. Further prospective or high-quality studies are required.
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| http://dx.doi.org/10.1007/s00405-024-08610-3 | DOI Listing |
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