We present an interesting case of a patient who was discharged from the hospital on daptomycin and ertapenem in the setting of osteomyelitis. The patient did not have any respiratory symptoms during that hospital stay. A few weeks after discharge, the patient came back to the hospital with complaints of fever and shortness of breath. Chest X-ray showed pulmonary infiltrates. Initially, the patient was treated for acute respiratory distress syndrome (ARDS) vs pneumonia, but she did not improve. When labs showed significant eosinophilia, daptomycin-induced eosinophilic pneumonia became the working diagnosis, and the patient improved significantly when daptomycin was discontinued and steroids were started.
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| http://dx.doi.org/10.7759/cureus.55298 | DOI Listing |
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Association between age and onset of daptomycin-induced adverse events using the U.S. food and drug administration adverse event reporting system.
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Department of Pharmacy, Mie University Hospital, Mie, Japan; Department of Clinical Pharmaceutics, Division of Clinical Medical Science, Mie University Graduate School of Medicine, Mie, Japan.
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- Daptomycin, a broad-spectrum antibiotic, was evaluated for age-related adverse events through analysis of 7307 reports from the FDA's Adverse Event Reporting System.
- The study found that older adults (65-80 years) experienced increased reports of eosinophilic pneumonia and acute renal failure, while adolescents (12-17 years) saw higher instances of anaphylactic reactions and pseudomembranous colitis.
- The results suggest the importance of age-dependent follow-up care to better manage and support daptomycin treatment for different age groups.
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