Cesta CE, Rotem R, Bateman BT, et al. JAMA Intern Med. 2024;184:144-152. 38079178.
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Maternal periconception hyperglycemia, preconception diabetes, and risk of major congenital malformations in offspring.
Hum Reprod
December 2024
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Study Question: What are the roles of maternal preconception diabetes and related periconceptional hyperglycemia on the risk of major congenital malformations (MCMs) in offspring?
Summary Answer: Maternal periconceptional glycated hemoglobin (HbA1c) levels over 5.6% were associated with an increased risk of congenital heart defects (CHD) in the offspring, and maternal preconception diabetes was associated with an increased risk of CHD, including when HbA1c levels were within euglycemic ranges.
What Is Known Already: Maternal preconception diabetes has been linked with MCMs in the offspring.
In T2DM, periconceptional, noninsulin, second-line antidiabetes medications were not linked to major congenital malformations vs. insulin.
Ann Intern Med
April 2024
Mayo Clinic, Rochester, Minnesota, USA (A.M.E.).
Cesta CE, Rotem R, Bateman BT, et al. JAMA Intern Med. 2024;184:144-152.
View Article and Find Full Text PDFAssociation between the introduction of a structured form and the quality of diabetes in pregnancy clinic care.
Intern Med J
August 2020
Department of Endocrinology, Campbelltown Hospital, New South Wales, Australia.
Background: Pregnancy in women with pre-gestational types 1 (T1DM) and 2 (T2DM) diabetes mellitus can be a clinical challenge. This study assessed the association between introducing a structured diabetes in pregnancy proforma, on the quality of medical record documentation and pregnancy outcomes in women with T1DM and T2DM.
Aims: To evaluate the impact of a proforma on the quality of documenting medical records and pregnancy/neonatal outcomes in women with pre-gestational diabetes.
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