Introduction: Distal junctional failure (DJF) is underreported when compared to proximal junctional failure. DJF arising due to spondylodiscitis has never been reported in the literature.
Case Report: A 45-year-old lady with a body mass index of 33 presented with a long-standing inability to walk due to myelopathy secondary to continuous ossified posterior longitudinal ligament and ossified ligamentum flavum. Posterior fusion and laminectomy were done from D2 to L2. She had an initial wound breakdown with a surgical site infection, but after 6 weeks, she developed spondylodiscitis at the distal instrumented vertebra, leading to DJF. She was started on appropriate antibiotics and an extension of fusion.
Conclusion: This report demonstrates and discusses the management of a rare case of DJF arising due to spondylodiscitis of the last instrumented vertebra.
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http://dx.doi.org/10.13107/jocr.2024.v14.i03.4320 | DOI Listing |
Renewed scientific interest in sympathetic modulation of muscle and neuromuscular junctions has spurred a flurry of new discoveries with major implications for motor diseases. However, the role sympathetic axons play in the persistent dysfunction that occurs after nerve injuries remains to be explored. Peripheral nerve injuries are common and lead to motor, sensory, and autonomic deficits that result in lifelong disabilities.
View Article and Find Full Text PDFJ Esthet Restor Dent
January 2025
Operative Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
Objective: To investigate the effect of cervical margin relocation with four different injectable restorative materials on the fracture resistance of molars receiving mesio-occluso-distal CAD/CAM nanoceramic onlay restorations.
Materials And Methods: One hundred and five sound mandibular molars received a standardized mesio-occluso-distal onlay preparation, with cervical margins located 2 mm apical to the cemento-enamel junction. The molars were randomly allocated into five groups (n = 21) according to the cervical relocating materials used: Group I had no cervical margin relocation; Group II used a highly viscous glass ionomer; Group III used a highly-filled injectable resin composite; Group IV used a resin-modified glass ionomer; and Group V used a bioactive ionic resin.
Int Urol Nephrol
January 2025
Department of Urology, Başkent University Alanya Application and Research Center, Antalya, Turkey.
Purpose: To investigate the effect of the degree of hydronephrosis on extracorporeal shockwave lithotripsy (SWL) success in patients who underwent SWL due to upper ureteral stones.
Methods: Medical records of 878 patients who underwent SWL were retrospectively reviewed. Patients with isolated unilateral 6-10 mm radiopaque upper ureteral stones above the upper border of the sacroiliac joint were included in the study.
Phytomedicine
December 2024
Univ Coimbra, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, Azinhaga de S. Comba, Coimbra 3000-548, Portugal; Univ Coimbra, Center for Innovative Biomedicine and Biotechnology (CIBB), Coimbra, Portugal; Clinical Academic Centre of Coimbra (CACC), Coimbra, Portugal.
Background: Pulmonary Arterial Hypertension (PAH) is characterized by pulmonary vascular remodelling, often associated with disruption of BMPR2/Smad1/5 and BMPR2/PPAR-γ signalling pathways that ultimately lead to right ventricle failure. Disruption of intercellular junctions and communication and a pro-angiogenic environment are also characteristic features of PAH. Although, current therapies improve pulmonary vascular tone, they fail to tackle other key pathological features that could prevent disease progression.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg Cases
January 2025
Osaka Metropolitan University Graduate School of Medicine, 1-4-3, Asahimachi, Abeno-Ku, Osaka, 545-8585, Japan.
Background: Repair of the regurgitant bicuspid aortic valve is an attractive alternative to valve replacement. Although good long-term outcomes have been reported, postoperative aortic stenosis remains a major late cause of repair failure in bicuspid aortic valves. Sinus plication is effective for creating a more symmetrical commissural angle, leading to a decrease in the mean transvalvular pressure gradient.
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