AI Article Synopsis
- Blume is recognized for its medicinal properties, particularly in treating neurological disorders like Alzheimer's disease (AD).
- Seven novel gastrodin derivatives were identified, including one unique compound, with their structures confirmed through advanced analytical techniques like NMR and mass spectrometry.
- Two of the identified compounds displayed neuroprotective effects and showed promising interactions with key targets related to Alzheimer's disease.
Article Abstract
Blume () is a well-known medicine food homology plant widely used in treating neurological disorders such as Alzheimer's disease (AD). Here, undiscovered gastrodin derivatives were systematically studied. Seven novel gastrodin derivatives (-), including a unique gastrodin isocitrate () and six differently substituted parishin derivatives (-), were isolated. Structural identification was mainly based on 1D and 2D NMR data, high-resolution ESI-MS data, and HPLC analysis. Notably, the stereochemistry of was further elucidated by ECD calculations. Compounds and showed neuroprotective effects on the HO-induced PC12 cell injury model. Molecular docking analysis exhibited that and had good affinities with three popular AD-related targets. These findings not only enriched the chemical diversity but also revealed potential active components in .
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976414 | PMC |
| http://dx.doi.org/10.1021/acsomega.4c00436 | DOI Listing |
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