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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field H NMR Investigation.
Metabolites
December 2024
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Since the biological activities and toxicities of 'foreign' and/or excess levels of metal ions are predominantly determined by their precise molecular nature, here we have employed high-resolution H NMR analysis to explore the 'speciation' of paramagnetic Ni(II) ions in human saliva, a potentially rich source of biomolecular Ni(II)-complexants/chelators. These studies are of relevance to the corrosion of nickel-containing metal alloy dental prostheses (NiC-MADPs) in addition to the dietary or adverse toxicological intake of Ni(II) ions by humans. Unstimulated whole-mouth human saliva samples were obtained from n = 12 pre-fasted (≥8 h) healthy participants, and clear whole-mouth salivary supernatants (WMSSs) were obtained from these via centrifugation.
View Article and Find Full Text PDFSalivary Glands: Function, Dysfunction, Regeneration, and Repair.
Discov Med
January 2025
Department of Stomatology, Faculty of Dentistry, University of Murcia, 30008 Murcia, Spain.
Salivary gland dysfunctions are common conditions variously related to aging, inflammatory players, and any other factor able to alter their normal physiology. These conditions may significantly impact oral and systemic health, affecting the overall quality of life. Over time, numerous therapeutic strategies have been explored to regenerate, repair, or replace injured salivary glands, focusing on those molecular and cellular mechanisms able to be safely translated into a clinical landscape.
View Article and Find Full Text PDFBiofilm architecture and dynamics of the oral ecosystem.
BioTechnologia (Pozn)
December 2024
Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal, India School of Life Sciences, Sambalpur University, Burla, Odisha, India.
The oral cavity, being a nutritionally enriched environment, has been proven to be an ideal habitat for biofilm development. Various microenvironments, including dental enamel, supra- and subgingival surfaces, salivary fluid, and the dorsal surface of the tongue, harbor diverse microbes. These biofilms typically consist of four major layers.
View Article and Find Full Text PDFEngineering 3D microtip gates of all-polymer organic electrochemical transistors for rapid femtomolar nucleic-acid-based saliva testing.
Biosens Bioelectron
January 2025
School of Materials Science and Engineering and Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Sun Yat-sen University, Guangzhou, 510275, PR China. Electronic address:
Point-of-care testing (POCT) of trace amount of biomarkers in biofluids is critical towards health monitoring and early diagnosis. In particular, to facilitate non-invasive saliva testing, the development of low-cost, lightweight and disposable biosensors is in urgent need, while the ultrahigh sensitivity beyond conventional clinical tests remains a great challenge. Herein, we demonstrate a simple and fully printable all-polymer organic electrochemical transistor (OECT) biosensor to detect femtomolar (fM)-level biomolecules in saliva within a few minutes by employing highly conducting lithium bis(trifluoromethanesulfonyl)imide (LiTFSI)-doped poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) serving as both the channel and gate.
View Article and Find Full Text PDFEffects of photobiomodulation and bethanechol chloride treatment on salivary composition and flow rate in head and neck cancer patients undergoing radiotherapy: longitudinal interventional experimental clinical study.
Support Care Cancer
January 2025
Department of Stomatology, Federal University of Paraná, Av. Prefeito Lothário Meissner, 632, 80210-170, Curitiba, PR, Brazil.
Objective: To evaluate the efficacy of photobiomodulation therapy (PBMT) and bethanechol chloride (BC) on the quantity and quality of saliva in patients undergoing radiotherapy (RT) for head and neck cancer.
Methods: Saliva samples were collected from patients before and after RT, who were treated with PBMT or BC. Clinical parameters, including salivary flow rate (SFR), pH, xerostomia, and concentrations of macro and microelements in saliva, were assessed.
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