AI Article Synopsis
- Metal oxide nanoparticles, specifically TiO2NPs, ZnONPs, IONs, and AlONPs, were studied for their effects on mRNA expression of CYP 1A1 in rat liver after oral administration.
- Male Albino rats were divided into groups and dosed with varying amounts of these nanoparticles for 60 days, while a control group did not receive any treatment.
- Results showed that all treated groups had increased levels of CYP 1A1 expression compared to the control, with ZnONPs causing the highest increase and TiO2NPs the lowest, indicating differing toxicity levels among the nanoparticles.
Article Abstract
Introduction: Metal oxide nanoparticles are currently used widely in many aspects of human and animal life with broad prospects for biomedical purposes. The present work was carried out to investigate the effects of orally administrated TiO2NPs, ZnONPs, IONs and AlONPs on the mRNA expression level of CYP 1A1 and in the rat liver.
Materials And Methods: Four groups of male Albino rats were given their respective treatment orally for 60 days in a dose of 1/20 of the LD50 TiO2NPs (600 mg/Kg b.wt/day), ZnONPs (340 mg/Kg b.wt/day), IONs (200 mg/kg b.wt/day) and AlONPs (100 mg/Kg b.wt/day) and a fifth group served as a control group.
Rresults: The mRNA level of CYP 1A1 and showed up-regulation in all the NPs-treated groups relative to the control group. ZnONPs group recorded the highest expression level while the TiO2NPs group showed the lowest expression level transcript. Conclusion:The toxic effects produced by these nanoparticles were more pronounced in the case of zinc oxide, followed by aluminum oxide, iron oxide nanoparticles and titanium dioxide, respectively.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10980790 | PMC |
| http://dx.doi.org/10.1093/toxres/tfae034 | DOI Listing |
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