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Mucosal sugars delineate pyrazine vs pyrazinone autoinducer signaling in Klebsiella oxytoca.
Nat Commun
October 2024
Department of Chemistry, Yale University, New Haven, CT, USA.
Virulent Klebsiella oxytoca strains are associated with gut and lung pathologies, yet our understanding of the molecular signals governing pathogenesis remains limited. Here, we characterized a family of K. oxytoca pyrazine and pyrazinone autoinducers and explored their roles in microbial and host signaling.
View Article and Find Full Text PDFDeciphering the Biosynthesis and Physiological Function of 5-Methylated Pyrazinones Produced by Myxobacteria.
ACS Cent Sci
March 2024
State Key Laboratory of Microbial Technology, Institute of Microbial Technology, Shandong University, 266237 Qingdao, P.R. China.
Article Synopsis
- Myxobacteria are tiny bacteria that can make complicated chemicals with many interesting uses, and this study focused on a special chemical called coralinone found in one type of myxobacteria named SDU70.
- The researchers discovered how coralinone is made and that it helps myxobacteria stick together more by increasing a special substance they produce.
- They also found a gene that helps myxobacteria protect themselves from the effects of coralinone, showing how these bacteria may evolve to keep their environment in balance.
Pyrazinone Biosynthesis and Signaling-Myxo Style.
ACS Cent Sci
March 2024
Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, Florida 32611, United States.
Small NRPS-like enzymes in sections and selectively form substituted pyrazinone metabolites.
Front Fungal Biol
October 2022
Food and Feed Safety Research, Southern Regional Research Center, Agricultural Research Service, United States Department of Agriculture (USDA), New Orleans, LA, United States.
fungi produce mycotoxins that are detrimental to human and animal health. Two sections of aspergilli are of particular importance to cereal food crops such as corn and barley. section species like and produce aflatoxins, while section species like and produce ochratoxin A.
View Article and Find Full Text PDFCellular Stress-Induced Metabolites in .
J Nat Prod
November 2022
Department of Chemistry, Yale University, New Haven, Connecticut 06520, United States.
isolates commonly inhabit the human microbiota, yet the majority of 's small-molecule repertoire remains uncharacterized. We previously employed erythromycin-induced translational stress to facilitate the characterization of autoinducer-3 (AI-3) and structurally related pyrazinones derived from "abortive" tRNA synthetase reactions in pathogenic, commensal, and probiotic isolates. In this study, we explored the "missing" tryptophan-derived pyrazinone reaction and characterized two other families of metabolites that were similarly upregulated under erythromycin stress.
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