Invasive aspergillosis (IA) is the most severe type of infection. Yunnan has developed agriculture, and the proportion of triazole-resistant induced by triazole fungicides is much higher than that in other regions of China. Inhalation of triazole-resistant is one of the main factors inducing IA. We gathered five strains of from the sputum or bronchoalveolar lavage fluid (BALF) of patients with IA in Yunnan. Subsequent testing showed that all of these strains were resistant to triazoles and harboured mutations in the tandem repeat sequence of the promoter region, suggesting that they may be triazole-resistant present in the environment.
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http://dx.doi.org/10.1080/21501203.2023.2299472 | DOI Listing |
Infect Drug Resist
October 2024
Department of Laboratory Medicine, Chongqing Health Center for Women and Children, Women and Children's Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Purpose: Candida vaginitis is widely prevalent worldwide and is one of the common gynecological disorders. The aim of this study is to analyze the sensitivity of recurrent vulvovaginal (RVVC) candidiasis to antifungal drugs and its relationship with vaginal microbiota.
Patients And Methods: We Isolated and cultured Candida from RVVC patients, mass spectrometry and broth microdilution method were used to identify and determine MIC values of antifungal drugs.
J Eur Acad Dermatol Venereol
August 2024
Fundación Vithas, Grupo Hospitalario Vithas, Madrid, Spain.
Background: Nakaseomyces glabratus (N. glabratus) formerly known as Candida glabrata (C. glabrata), is an endogenous opportunistic pathogen, which is generally located in the gastrointestinal tract but can spread in immunocompromised patients.
View Article and Find Full Text PDFmBio
July 2024
Microbiology and Immunology Department, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Contemporary antifungal therapies utilized to treat filamentous fungal infections are inhibited by intrinsic and emerging drug resistance. Consequently, there is an urgent need to develop novel antifungal compounds that are effective against drug-resistant filamentous fungi. Here, we utilized an cell-based high-throughput screen to identify small molecules with antifungal activity that also potentiated triazole activity.
View Article and Find Full Text PDFAppl Environ Microbiol
May 2024
Fungal Biology Group, Plant Pathology Department, University of Georgia, Athens, Georgia, USA.
is a ubiquitous saprotroph and human-pathogenic fungus that is life-threatening to the immunocompromised. Triazole-resistant was found in patients without prior treatment with azoles, leading researchers to conclude that resistance had developed in agricultural environments where azoles are used against plant pathogens. Previous studies have documented azole-resistant across agricultural environments, but few have looked at retail plant products.
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