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Repeated photodynamic therapy using a chlorin e6-embedded device to prolong the therapeutic effects on obesity. | LitMetric

AI Article Synopsis

  • The study investigated the use of a chlorin e6 (Ce6)-embedded intragastric device for repeated photodynamic therapy (PDT) to treat obesity in juvenile pigs.
  • Twelve pigs were divided into four groups and received different schedules of PDT, with various measures taken to assess the therapy's effectiveness and safety.
  • Results showed that PDT significantly reduced body weight gain and altered hormone levels related to hunger and fat storage, with repeated treatments being both feasible and safe while minimizing complications.

Article Abstract

Objective: This study aimed to investigate the efficacy and safety of repeated photodynamic therapy (PDT) with a chlorin e6 (Ce6)-embedded intragastric satiety-inducing device (ISD) to maintain therapeutic effects of obesity in a juvenile pig.

Methods: The Ce6-embedded ISD was fabricated with a dipping method. Twelve pigs were divided into four groups of three and were administered control, single, biweekly, or weekly PDT, respectively. The therapeutic effects were assessed by comparing the results of phototoxicity, endoscopy, fluoroscopy, hormone and weight changes, and histological examination.

Results: The percentage of total body weight gain was significantly suppressed in PDT-treated pigs compared with control pigs (all p < 0.001). This suppression persisted in the repeated PDT groups, but percentage of total body weight gain gradually increased when PDT was stopped. Ghrelin levels in the PDT-treated groups were significantly lower and leptin levels were significantly higher than those in the control group (all p < 0.05). Inflammatory cell infiltration, collagen, TUNEL, and anti-ghrelin-positive deposition in the weekly group were significantly higher than those in the control, single, and biweekly groups (all p < 0.01).

Conclusions: Repeated and periodic PDT was technically feasible and safe and successfully maintained the therapeutic effects against obesity while eliminating the indwelling time and reducing ISD-related complications in pigs.

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Source
http://dx.doi.org/10.1002/oby.23958DOI Listing

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