AI Article Synopsis
- - Pediatric gliomas, including low-grade (pLGG) and high-grade (pHGG), are the most common brain tumors in children, leading to serious health issues.
- - Recent advancements in understanding the molecular biology of these tumors have led to improved treatment options, particularly for pLGG, and have focused on making therapies less toxic and more effective.
- - Next generation sequencing techniques are essential for developing these new treatments, aiming to enhance survival rates and quality of life for affected children.
Article Abstract
Pediatric gliomas, consisting of both pediatric low-grade (pLGG) and high-grade gliomas (pHGG), are the most frequently occurring brain tumors in children. Over the last decade, several milestone advancements in treatments have been achieved as a result of stronger understanding of the molecular biology behind these tumors. This review provides an overview of pLGG and pHGG highlighting their clinical presentation, molecular characteristics, and latest advancements in therapeutic treatments. Conclusion: The increasing understanding of the molecular biology characterizing pediatric low and high grade gliomas has revolutionized treatment options for these patients, especially in pLGG. The implementation of next generation sequencing techniques for these tumors is crucial in obtaining less toxic and more efficacious treatments. What is Known: • Pediatric Gliomas are the most common brain tumour in children. They are responsible for significant morbidity and mortality in this population. What is New: • Over the last two decades, there has been a significant increase in our global understanding of the molecular background of pediatric low and high grade gliomas. • The implementation of next generation sequencing techniques for these tumors is crucial in obtaining less toxic and more efficacious treatments, with the ultimate goal of improving both the survival and the quality of life of these patients.
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| http://dx.doi.org/10.1007/s00431-024-05540-4 | DOI Listing |
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