p24 family Tango(1) at the endoplasmic reticulum exit site to organize cargo exit.

J Cell Biol

Department of Biological Informatics and Experimental Therapeutics, Graduate School of Medicine, Akita University, Akita, Japan.

Published: May 2024

The p24 family of proteins have been regarded as cargo receptors for endoplasmic reticulum (ER) to Golgi transport; however, their precise functions have yet to be revealed. In this issue, Pastor-Pareja and colleagues (https://doi.org/10.1083/jcb.202309045) show that the interaction of these proteins with Tango1 is critical for their localization at the ER exit site (ERES) and efficient transport of secretory proteins in Drosophila.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10983802PMC
http://dx.doi.org/10.1083/jcb.202403016DOI Listing

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