AI Article Synopsis
- The study analyzed how mitochondrial DNA (mtDNA) haplogroups relate to weight gain and Body Mass Index (BMI) in 1,019 HIV-positive individuals who started first-line antiretroviral therapy (ART) since 2014.
- Over 96 weeks, participants experienced an average weight increase of 2.90 kg and a BMI increase of 0.98 kg/m².
- The results showed that a specific UK mtDNA haplogroup was significantly associated with less weight and BMI gain after starting ART, suggesting mitochondrial genetics could influence weight changes in people living with HIV.
Article Abstract
We studied the association of mitochondrial DNA (mtDNA) haplogroups with weight and body mass index (BMI) gain at 96 weeks in 1019 treatment-naive persons with HIV (PWH) who initiated first-line antiretroviral therapy (ART) since 2014. The mean increase in weight and BMI over the study period was 2.90 kg and 0.98 kg/m2, respectively. We found a significant adjusted association between the major UK mtDNA haplogroup and lower weight and BMI increase at 96 weeks after ART initiation. Our findings reveal a potential role for mitochondrial genetics in the complex phenomenon of weight gain after initial ART in PWH.
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| http://dx.doi.org/10.1093/infdis/jiae168 | DOI Listing |
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