AI Article Synopsis
- The study aimed to assess the safety and effectiveness of various treatments for diabetic retinopathy (DR) in patients undergoing cataract surgery.
- A search of randomized controlled trials revealed that anti-VEGF drugs significantly decreased DR progression and improved best corrected visual acuity (BCVA), while steroids effectively reduced macular thickness after surgery.
- The analysis concluded that anti-VEGF drugs demonstrate promise in managing DR during cataract surgery, but more extensive studies are needed for better comparisons of treatment options.
Article Abstract
Purpose: To evaluate the safety and effectiveness of various treatment modalities in patients with diabetic retinopathy (DR) who underwent cataract surgery.
Methods: A comprehensive search for randomized controlled trials (RCTs) was conducted using the PubMed, Embase, Cochrane Library, and CNKI databases up to December 22, 2021. The safety and efficacy of treatment modalities were assessed using the risk ratio (RR) to compare the progression of DR and the mean difference to evaluate the best corrected visual acuity (BCVA) and macular thickness (MT).
Results: The meta-analysis of the RCTs revealed that anti-VEGF (anti-vascular endothelial growth factor) drugs significantly reduced the progression of DR [RR: 0.37 (95%CI 0.19, 0.70), P = 0.002] and improved BCVA [mean difference = - 0.06 (- 0.12, - 0.01), P = 0.03] in patients with pre-existing DR who underwent cataract surgery. Steroid drugs also showed a significant reduction in macular thickness [mean difference = - 55.63 (- 90.73, - 20.53), I = 56%, P = 0.002] in DR patients two weeks after cataract surgery compared to the control group. The safety profiles of different management options did not differ significantly.
Conclusion: The present meta-analysis suggests that anti-VEGF drugs can effectively slow down the progression of diabetic retinopathy, improve BCVA, and reduce MT in DR patients who underwent cataract surgery. Steroid drugs also show promise in reducing MT. However, further studies with larger sample sizes are required to compare the efficacy and safety of different management options in a multi-center clinical setting.
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| http://dx.doi.org/10.1007/s10792-024-02981-6 | DOI Listing |
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