AI Article Synopsis
- - Rutin, a flavonoid found in many fruits and vegetables, is commonly taken as a dietary supplement, with suggested doses ranging from 250-500 mg/day, due to its reported health benefits.
- - This paper is the first to analyze the dose-response relationship of rutin, outlining its biological effects and potential implications for health and medicine.
- - The research highlights that while beneficial effects of rutin are observed in lab studies, humans may not experience the same benefits due to low absorption in the digestive system, suggesting a need for more tailored future research.
Article Abstract
Rutin is a flavonoid present in numerous fruits and vegetables and therefore widely consumed by humans. It is also a popular dietary supplement of 250-500 mg/day. There is considerable consumer interest in rutin due to numerous reports in the biomedical literature of its multi-system chemo-preventive properties. The present paper provides the first assessment of rutin-induced hormetic concentration/dose responses, their quantitative features and mechanistic basis, along with their biological, biomedical, clinical, and public health implications. The findings indicate that rutin-induced hormetic dose responses are widespread, being reported in numerous biological models and cell types for a wide range of endpoints. Of critical importance is that the optimal hormetic findings shown in in vitro systems are currently not achievable for human populations due to low gastrointestinal tract bioavailability. These findings have the potential to strengthen future experimental studies with rutin, particularly concerning study design parameters.
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| http://dx.doi.org/10.1016/j.fct.2024.114626 | DOI Listing |
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