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Single Exposure to Low-Intensity Focused Ultrasound Causes Biphasic Opening of the Blood-Brain Barrier Through Secondary Mechanisms.
Pharmaceutics
January 2025
Department of Pharmaceutical Sciences, West Virginia University School of Pharmacy, Morgantown, WV 26505, USA.
The blood-brain barrier (BBB) is selectively permeable, but it also poses significant challenges for treating CNS diseases. Low-intensity focused ultrasound (LiFUS), paired with microbubbles is a promising, non-invasive technique for transiently opening the BBB, allowing enhanced drug delivery to the central nervous system (CNS). However, the downstream physiological effects following BBB opening, particularly secondary responses, are not well understood.
View Article and Find Full Text PDFInjectable Tumoricidal Neural Stem Cell-Laden Hydrogel for Treatment of Glioblastoma Multiforme-An In Vivo Safety, Persistence, and Efficacy Study.
Pharmaceutics
December 2024
Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC 27599, USA.
Background/objectives: Glioblastoma multiforme (GBM) is the most common high-grade primary brain cancer in adults. Despite efforts to advance treatment, GBM remains treatment resistant and inevitably progresses after first-line therapy. Induced neural stem cell (iNSC) therapy is a promising, personalized cell therapy approach that has been explored to circumvent challenges associated with the current GBM treatment.
View Article and Find Full Text PDFFabrication and In Vivo Evaluation of In Situ pH-Sensitive Hydrogel of Sonidegib-Invasomes via Intratumoral Delivery for Basal Cell Skin Cancer Management.
Pharmaceuticals (Basel)
December 2024
Department of Pharmaceutics and Drug Manufacturing, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo 11435, Egypt.
Background/objectives: Basal cell skin cancer (BCSC) develops when skin cells proliferate uncontrollably. Sonidegib (SDB) is a therapeutic option for the treatment of BCSC by inhibiting hedgehog signaling. The problems with SDB's low solubility, poor bioavailability, resistance, poor targeting, and first-pass action make it less effective when taken orally.
View Article and Find Full Text PDFDiversity of the Amoebozoa and Ciliophora Groups in Non-Human Primates Kept Ex Situ and in Their Handlers in Different Institutions in Brazil.
Pathogens
January 2025
Laboratory of Protozoology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Av. Brasil, 4365, Rio de Janeiro 21040-360, RJ, Brazil.
Parasitic infections in non-human primates (NHPs) kept ex situ can be caused by zoonotic protists like and . In Brazil, little is known about these infections in neotropical species. This study aimed to identify Amoebozoa and Ciliophora groups in fecal samples through in vitro isolation and molecular analysis, mapping their distribution in Brazil.
View Article and Find Full Text PDFGravelSens: A Smart Gravel Sensor for High-Resolution, Non-Destructive Monitoring of Clogging Dynamics.
Sensors (Basel)
January 2025
Faculty of Architecture and Civil Engineering, Karlsruhe University of Applied Sciences, 76133 Karlsruhe, Germany.
Engineers, geomorphologists, and ecologists acknowledge the need for temporally and spatially resolved measurements of sediment clogging (also known as colmation) in permeable gravel-bed rivers due to its adverse impacts on water and habitat quality. In this paper, we present a novel method for non-destructive, real-time measurements of pore-scale sediment deposition and monitoring of clogging by using wire-mesh sensors (WMSs) embedded in spheres, forming a smart gravel bed (GravelSens). The measuring principle is based on one-by-one voltage excitation of transmitter electrodes, followed by simultaneous measurements of the resulting current by receiver electrodes at each crossing measuring pores.
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