AI Article Synopsis
- Eya family proteins, including Eyas1-4, are crucial in embryonic development, influencing cell growth, movement, survival, and the ability of cells to change states.
- Their diverse roles stem from their functions as transcriptional co-factors and phosphatases, which modify other proteins to regulate various cellular processes.
- Re-expression of Eya proteins is linked to various cancers, where they help tumors grow by reactivating developmental pathways, making them potential targets for cancer treatment.
Article Abstract
The Eya family of proteins (consisting of Eyas1-4 in mammals) play vital roles in embryogenesis by regulating processes such as proliferation, migration/invasion, cellular survival and pluripotency/plasticity of epithelial and mesenchymal states. Eya proteins carry out such diverse functions through a unique combination of transcriptional co-factor, Tyr phosphatase, and PP2A/B55α-mediated Ser/Thr phosphatase activities. Since their initial discovery, re-expression of Eyas has been observed in numerous tumor types, where they are known to promote tumor progression through a combination of their transcriptional and enzymatic activities. Eya proteins thus reinstate developmental processes during malignancy and represent a compelling class of therapeutic targets for inhibiting tumor progression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11111358 | PMC |
| http://dx.doi.org/10.1016/j.bbcan.2024.189098 | DOI Listing |
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