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| http://dx.doi.org/10.1186/s40478-024-01752-9 | DOI Listing |
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Correction: Pyroptosis in Alzheimer's disease: cell type‑specific activation in microglia, astrocytes and neurons.
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Division of Spine Surgery, Department of Orthopaedics, University of Maryland Medical Center, 110 South Paca Street, Suite 300, Baltimore, MD, 21201, USA.
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View Article and Find Full Text PDFAlzheimer's disease (AD) is a multifactorial neurodegenerative disorder characterized by heterogeneous molecular changes across diverse cell types, posing significant challenges for treatment development. To address this, we introduced a cell-type-specific, multi-target drug discovery strategy grounded in human data and real-world evidence. This approach integrates single-cell transcriptomics, drug perturbation databases, and clinical records.
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