AI Article Synopsis
- Injectable hydrogels made from maleimidyl alginate and gelatin can self-crosslink easily without the need for catalysts, making them convenient to use in clinical settings.
- These hydrogels are strong, bioadhesive, and can withstand conditions like bending and boiling, making them suitable for various medical applications, including skin defects.
- Furthermore, they promote cell growth and healing, showing effectiveness in speeding up the recovery of diabetic skin wounds, indicating their potential in improving healthcare outcomes.
Article Abstract
Injectable hydrogels have wide applications in clinical practice. However, the development of tough and bioadhesive ones based on biopolymers, along with biofriendly and robust crosslinking strategies, still represents a great challenge. Herein, we report an injectable hydrogel composed of maleimidyl alginate and pristine gelatin, for which the precursor solutions could self-crosslink via mild Michael-type addition without any catalyst or external energy upon mixing. This hydrogel is tough and bioadhesive, which can maintain intactness as well as adherence to the defect of porcine skin under fierce bending and twisting, warm water bath, and boiling water shower. Besides, it is biocompatible, bioactive and biodegradable, which could support the growth and remodeling of cells by affording an extracellular matrix-like environment. As a proof of application, we demonstrate that this hydrogel could significantly accelerate diabetic skin wound healing, thereby holding great potential in healthcare.
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| http://dx.doi.org/10.1016/j.carbpol.2024.122011 | DOI Listing |
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