The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cell.2024.02.043 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
p53: A tale of complexity and context.
Cell
March 2024
Department of Biological Sciences, Columbia University, New York, NY, USA. Electronic address:
The story of p53 is illuminating. Despite widespread attention, the tumor-suppressive functions of wild-type p53 or the oncogenic activities of its cancer-associated mutants are still not fully understood, and our discoveries have not yet led to major therapeutic breakthroughs. There is still much to learn about this fascinating protein.
View Article and Find Full Text PDFTargeting p53 gain-of-function activity in cancer therapy: a cautionary tale.
Cell Death Differ
February 2024
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Utility of p53 immunohistochemistry as a surrogate for sequencing in myeloid neoplasms: A tale of caution.
Am J Hematol
February 2024
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Reprogramming of glycolysis by chemical carcinogens during tumor development.
Semin Cancer Biol
December 2022
Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India; Department of Biochemistry, All India Institute of Medical Sciences, Guwahati, Assam, India. Electronic address:
Indiscriminate usage and mismanagement of chemicals in the agricultural and industrial sectors have contaminated different environmental compartments. Exposure to these persistent and hazardous pollutants like heavy metals, endocrine disruptors, aromatic hydrocarbons, and pesticides can result in various health adversities, including cancer. Chemical carcinogens follow a similar pattern of carcinogenesis, like oxidative stress, chromosomal aberration, DNA double-strand break, mismatch repair, and misregulation of oncogenic and/or tumor suppressors.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!