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MEK signalling pathway is required for hypoblast specification and migration in ovine. | LitMetric

AI Article Synopsis

  • - The study investigates the role of the MEK signaling pathway in the differentiation of hypoblasts in ovine (sheep) embryos, as its function was already established in mouse embryos but was uncertain in ungulates.
  • - Researchers demonstrated that MEK signaling is essential for the specification of hypoblasts in the inner cell mass of the ovine blastocyst and is involved in hypoblast migration post-hatching.
  • - These findings suggest that the MEK signaling pathway's function in hypoblast differentiation is consistent across different mammalian species, indicating its evolutionary importance.

Article Abstract

In Brief: MEK signalling pathway is required for hypoblast differentiation in mouse embryos, but its role in ungulate embryos remains controversial. This paper demonstrates that MEK is required for hypoblast specification in the inner cell mass of the ovine blastocyst and that it plays a role during the hypoblast migration occurring following blastocyst hatching.

Abstract: Early embryo development requires the differentiation of three cell lineages in two differentiation events. The second lineage specification differentiates the inner cell mass into epiblast, which will form the proper fetus, and hypoblast, which together with the trophectoderm will form the extraembryonic membranes and the fetal part of the placenta. MEK signalling pathway is required for hypoblast differentiation in mouse embryos, but its role in ungulate embryos remains controversial. The aim of this work was to analyse the role of MEK signalling on hypoblast specification at the blastocyst stage and on hypoblast migration during post-hatching stages in vitro in the ovine species. Using well-characterized and reliable lineage markers, and different MEK inhibitor concentrations, we demonstrate that MEK signalling pathway is required for hypoblast specification in the inner cell mass of the ovine blastocyst, and that it plays a role during the hypoblast migration occurring following blastocyst hatching. These results show that the role of MEK signalling pathway on hypoblast specification is conserved in phylogenetically distant mammals.

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Source
http://dx.doi.org/10.1530/REP-24-0003DOI Listing

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