AI Article Synopsis
- Antiviral memory B cells are special cells in our immune system that help us remember and fight off viruses after we've been infected or vaccinated.
- Scientists studied these B cells to see what makes them different from other memory B cells, looking at both gene activity and changes in their DNA structure.
- They found that antiviral memory B cells have a stronger response to infections and need a protein called T-bet to develop properly, showing that they are unique compared to regular memory B cells.
Article Abstract
The long-lasting humoral immunity induced by viral infections or vaccinations depends on memory B cells with greatly increased affinity to viral antigens, which are evolved from germinal center (GC) responses. However, it is unclear whether antiviral memory B cells represent a distinct subset among the highly heterogeneous memory B cell population. Here, we examined memory B cells induced by a virus-mimicking antigen at both transcriptome and epigenetic levels and found unexpectedly that antiviral memory B cells exhibit an enhanced innate immune response, which appeared to be facilitated by the epigenetic memory that is established through the memory B cell development. In addition, T-bet is associated with the altered chromatin architecture and is required for the formation of the antiviral memory B cells. Thus, antiviral memory B cells are distinct from other GC-derived memory B cells in both physiological functions and epigenetic landmarks.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10980274 | PMC |
| http://dx.doi.org/10.1126/sciadv.adk0858 | DOI Listing |
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