AI Article Synopsis

  • The study analyzed diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BD) in adolescents and young adults using data from over 130,000 participants aged 10-29 in Taiwan.
  • Findings showed a 13.80% conversion rate over 11 years, with the highest rate of 4.50% occurring in the first year and declining thereafter.
  • Significant predictors of conversion included younger age at MDD diagnosis, antidepressant resistance, obesity, psychiatric comorbidities, a family history of mental disorders, lower income, and more frequent mental health visits, indicating different influential factors compared to adults.

Article Abstract

Although several studies have examined a diagnostic conversion from major depressive disorder (MDD) to bipolar disorder (BD), only a few studies specifically focused on adolescents and young adults who are at the peak ages of BD onset. Data from participants (N = 130,793) aged 10-29 years who were diagnosed with MDD were extracted from the Taiwan National Health Insurance Research Database. We applied demographic analyses, survival analysis, Aalen Johansen curves, and Cox regression, investigating the diagnostic conversion rate and factors that were most or less predictive of conversion. Among the adolescents and young adults with MDD, the number of participant conversion subsample is 14,187 and the conversion rate was 13.80% (95% confidence interval: 13.54-14.06%) during the 11-year follow-up. The conversion rate was highest in the first year (4.50%; 4.39-4.61%) and decreased over time. The significant predictors were younger age of diagnosis with MDD (p < 0.001), moderate and high antidepressant resistance (p < 0.001), obesity (p < 0.001), psychiatric comorbidities (attention-deficit/hyperactivity disorder, substance use disorder, and cluster B and C personality disorder, all p < 0.001), a family history of mental disorders (schizophrenia and mood disorders, all p < 0.05), lower monthly income (p < 0.001), and more mental health visits to the clinic each year (p < 0.001). A composite of demographic characteristics, antidepressant resistance, physical and psychiatric comorbidities, and family history significantly predicted diagnostic conversion from MDD to BD (area under the curve = 0.795, p < 0.001). Compared to adult population, the adolescents and young adults had different factors that were most or less predictive of conversion, which warrants further investigation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564236PMC
http://dx.doi.org/10.1007/s00787-024-02401-1DOI Listing

Publication Analysis

Top Keywords

diagnostic conversion
12
adolescents young
12
young adults
12
conversion rate
12
bipolar disorder
8
major depressive
8
depressive disorder
8
conversion
6
conversion bipolar
4
disorder
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!