AI Article Synopsis
- A new gold-catalyzed reaction for Suzuki-Miyaura coupling involving C(sp)-C(sp) bonds was created, using Au(I)/Au(III) redox catalysis with no external oxidants needed.
- This method enables the cross-coupling of alkyl organometallics, which was previously difficult, under mild conditions.
- The reaction can efficiently combine various alkyl chains and methyl trifluoroborates with aryl and vinyl iodides, expanding the possibilities for challenging couplings in organic chemistry.
Article Abstract
A gold-catalyzed C(sp)-C(sp) Suzuki-Miyaura coupling reaction facilitated by ligand-enabled Au(I)/Au(III) redox catalysis was developed. The cross-coupling of alkyl organometallics was first realized in the redox catalytic cycle in gold chemistry, without the use of external oxidants. This gold-catalyzed C(sp)-C(sp) coupling reaction allows a variety of alkyl chain and useful methyl trifluoroborates to react with aryl and vinyl iodides under very mild conditions, which provides a new reactivity pattern for challenging couplings with alkyl organometallics.
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| http://dx.doi.org/10.1021/acs.orglett.4c00755 | DOI Listing |
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