A Horn Peptide-Thermoresponsive Hydrogel for Angiogenesis and Bone Regeneration.

Adv Healthc Mater

Jiangsu Provincial Engineering Research Center of TCM External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing, 210023, P. R. China.

Published: July 2024

The management of critical-sized bone defects presents a formidable clinical challenge, especially given the increasing incidence of bone diseases in the aging population. Consequently, there is an increased demand for minimally invasive bone repair materials that can effectively address this challenge, particularly in outpatient settings. In this study, the goal is to develop an injectable and biodegradable biomaterial that adheres to and fills bone-defect sites to support bone regeneration. The osteogenic and angiogenic activities of animal horn peptides are investigated by incorporating them into biologically active moieties, in combination with a novel thermosensitive hydrogel. The resulting thermosensitive hydrogel exhibited essential biological functionalities, allowing precise modulation of its physical and chemical properties. Notably, the hydrogel incorporating the horn peptide rapidly filled the bone defect site, promoting both angiogenesis and bone induction. Consequently, this approach significantly accelerates new bone regeneration. In summary, the findings of this study present a promising, minimally invasive solution for addressing critical-sized bone defects.

Download full-text PDF

Source
http://dx.doi.org/10.1002/adhm.202304400DOI Listing

Publication Analysis

Top Keywords

bone regeneration
12
bone
9
angiogenesis bone
8
critical-sized bone
8
bone defects
8
minimally invasive
8
thermosensitive hydrogel
8
horn peptide-thermoresponsive
4
hydrogel
4
peptide-thermoresponsive hydrogel
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!