AI Article Synopsis
- Catheters struggle in complex vascular paths, making embolization difficult, so researchers developed a new multistage strategy using shape-memory magnetic microrobots (SMMs) that can swim to hard-to-reach spots.
- SMMs are biocompatible microrobots that start as linear shapes and quickly transform into helices at body temperature, allowing them to navigate tortuous vessels with helical propulsion.
- In trials with rabbits, SMMs successfully traveled 100 cm and performed renal artery embolization in just 2 minutes, maintaining their position for 4 weeks and reducing kidney size by 36%.
Article Abstract
Catheters navigating through complex vessels, such as sharp turns or multiple U-turns, remain challenging for vascular embolization. Here, we propose a novel multistage vascular embolization strategy for hard-to-reach vessels that releases untethered swimming shape-memory magnetic microrobots (SMMs) from the prior catheter to the vessel bifurcation. SMMs, made of organo-gel with magnetic particles, ensure biocompatibility, radiopacity, thrombosis, and fast thermal and magnetic responses. An SMM is initially a linear shape with a 0.5-mm diameter at 20 °C inserted in a catheter. It transforms into a predetermined helix within 2 s at 38 °C blood temperature after being pushed out of the catheter into the blood. SMMs enable agile swimming in confined and tortuous vessels and can swim upstream using helical propulsion with rotating magnetic fields. Moreover, we validated this multistage vascular embolization in living rabbits, completing 100-cm travel and renal artery embolization in 2 min. After 4 weeks, the SMMs maintained the embolic position, and the kidney volume decreased by 36%.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976590 | PMC |
| http://dx.doi.org/10.34133/research.0339 | DOI Listing |
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