Alpha-synuclein plays a pivotal role in Parkinson's disease (PD) pathogenesis, with α-synuclein aggregates/oligomers being identified as toxic species and phosphorylation at Serine 129 promoting aggregation/oligomerization. We investigated the biochemical profile of α-synuclein in the "weaver" mouse, a genetic PD model. Our results revealed increased Serine 129 phosphorylation in the midbrain, striatum, and cortex at a phase of established dopaminergic degeneration on postnatal day 100. These results indicate α-synuclein pathology already at this stage and the potential for age-related progress. Our findings confirm that the "weaver" mouse is an invaluable genetic model to study α-synuclein pathogenesis during PD progression.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973874 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.001156 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A safe insect-based chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques.
NPJ Vaccines
December 2024
Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX, 77555, USA.
Eilat (EILV)/chikungunya virus (CHIKV), an insect-based chimeric alphavirus was previously reported to protect mice months after a single dose vaccination. The underlying mechanisms of host protection are not clearly defined. Here, we assessed the capacity of EILV/CHIKV to induce quick and durable protection in cynomolgus macaques.
View Article and Find Full Text PDFStructure-Activity Relationship Studies in a Series of 2-Aryloxy--(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels.
Molecules
November 2024
Department of Pharmaceutical Sciences, UNT System College of Pharmacy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the gene. encodes the sodium-activated potassium channel known as SLACK, making small molecule inhibitors of SLACK channels a compelling approach to the treatment of EIMFS and other epilepsies associated with mutations. In this manuscript, we describe a hit optimization effort executed within a series of 2-aryloxy--(pyrimidin-5-yl)acetamides that were identified via a high-throughput screen.
View Article and Find Full Text PDFAntiviral and immunomodulatory effects of ouabain against congenital Zika syndrome model.
Mol Ther
December 2024
Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch (UTMB), Galveston, TX 77555, USA. Electronic address:
Zika virus (ZIKV) is an arbovirus associated with neurological disorders accompanying congenital infections. With no vaccine or antiviral approved, there is an urgent need for the development of effective antiviral agents against ZIKV infection. We evaluated the anti-ZIKV and immunomodulatory activity of ouabain, a Na/K-ATPase inhibitor known to have immunomodulatory and antiviral activities, using human neural stem and progenitor cells (hNS/PCs) and a murine model of congenital Zika syndrome (CZS).
View Article and Find Full Text PDFEnsembl 2025.
Nucleic Acids Res
December 2024
European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Ensembl (www.ensembl.org) is an open platform integrating publicly available genomics data across the tree of life with a focus on eukaryotic species related to human health, agriculture and biodiversity.
View Article and Find Full Text PDFLung contusion complicated by pneumonia worsens lung injury via the inflammatory effect of alveolar small extracellular vesicles on macrophages and epithelial cells.
J Trauma Acute Care Surg
January 2025
From the Division of Trauma, Surgical Critical Care, Burns and Acute Care Surgery, Department of Surgery (K.N., W.C., W.J., K.P., D.P., J.W., B.E., T.C.), UC San Diego School of Medicine, San Diego; Comparative Effectiveness and Clinical Outcomes Research Center (R.C.), Riverside University Health System, Loma Linda University School of Medicine, Riverside, California; and Trauma and Acute Critical Care Center (K.N.), Tokyo Medical and Dental University Hospital, Bunkyo-ku, Tokyo, Japan.
Background: Lung contusion (LC) complicated by pneumonia is associated with a higher risk of acute lung injury (ALI) mediated by activation of immune cells and injury to the lung epithelium. Small extracellular vesicles (sEVs) are essential mediators of cellular crosstalk; however, their role in the development of postinjury ALI remains unclear. We hypothesized that LC complicated by pneumonia increases the pro-inflammatory effect of alveolar sEVs on macrophages and the cytotoxicity of alveolar sEVs to pulmonary epithelial cells, worsening the severity of ALI.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!