AI Article Synopsis

  • - Human enterovirus (EV) and Parechovirus (PeV) infections are significant contributors to sepsis-like illness in infants under 90 days old, with EV-B being the main cause of aseptic meningitis in young infants.
  • - In Thailand, routine screenings for EV and PeV in cases of suspected aseptic meningitis and sepsis-like illness are not conducted, resulting in limited epidemiological data.
  • - A study conducted from 2013 to 2022 found that 10.5% of hospitalized infants tested positive for EV, primarily EV-B, while no cases of PeV or Herpes simplex virus (HSV) were detected.

Article Abstract

Human enterovirus (EV) and Parechovirus (PeV) infections are major causes of sepsis-like illness in infants < 90 days of age. Enterovirus species B (EV-B) was found to be the leading cause of aseptic meningitis in young infants. In Thailand, EV and PeV are not part of the routine screening of blood or cerebrospinal fluid (CSF) of children with suspected aseptic meningitis and sepsis-like illness. Consequently, data on EV and PeV epidemiology are limited. This study tested clinical samples from hospitalized young infants with suspected aseptic meningitis or sepsis-like illness between 2013 and 2022 for EV, PeV, and Herpes simplex virus (HSV). Of 95 specimens, 10 were positive for EV, representing 10.5%. These positive samples included eight CSF and two stool samples. No samples were positive for PeV and HSV. Of these positive cases, EV-B was detected in eight, and EV-A was detected in two cases. The species of EV-B detected include echovirus-18 (E18) (n=2), E21 (n=2), E4(n=1), E5 (n=1), E9 (n=1), and E11 (n=1). Our report demonstrates the significant role of EV-B, and less frequently EV-A, in Thai infants with aseptic meningitis and sepsis-like illness.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973795PMC
http://dx.doi.org/10.7759/cureus.54997DOI Listing

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