Both sotorasib and adagrasib are approved for use in metastatic -mutated NSCLC after cancer progression on chemotherapy and immunotherapy. Hepatoxicity is a commonly encountered adverse effect of both agents, and little data exists about the safety of sequential use of these agents when hepatotoxicity is encountered. In this case report, we describe a patient who developed recurrent hepatotoxicity with sotorasib and was able to switch to adagrasib without hepatotoxicity and subsequently experienced a prolonged cancer response. We also describe a previously unreported adagrasib adverse effect of photoinduced skin hyperpigmentation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973652 | PMC |
| http://dx.doi.org/10.1016/j.jtocrr.2024.100661 | DOI Listing |
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