AI Article Synopsis
- The study investigates how genetic variations (SNPs) in the melatonin receptor gene might influence the development of microvascular complications in individuals with type 1 diabetes (T1D).
- It involves examining eight specific SNPs in a cohort of 489 T1D patients, looking at both current complications and long-term kidney function over an average of eight years.
- Results indicate that individuals with a significant decline in kidney function have a higher frequency of a specific genetic variant (A allele of rs4862705), suggesting a potential link between melatonin genetics and renal health in diabetes.
Article Abstract
Aim: The pathogenesis of chronic diabetes complications has oxidative stress as one of the major elements, and single-nucleotide polymorphisms (SNPs) in genes belonging to antioxidant pathways modulate susceptibility to these complications. Considering that melatonin is a powerful antioxidant compound, our aim was to explore, in a longitudinal cohort study of type 1 diabetes (T1D) individuals, the association of microvascular complications and SNPs in the gene encoding melatonin receptor 1A ().
Methods: Eight SNPs in were genotyped in 489 T1D individuals. Besides cross-sectional analyses of SNPs with each one of the microvascular complications (distal polyneuropathy, cardiovascular autonomic neuropathy, retinopathy, and diabetic kidney disease), a longitudinal analysis evaluated the associations of SNPs with renal function decline in 411 individuals followed up for a median of 8 years. In a subgroup of participants, the association of complications with urinary 6-sulfatoxymelatonin (aMT6s) concentration was investigated.
Results: The group of individuals with a renal function decline ≥ 5 mL min 1.73 m year presented a higher frequency of the A allele of rs4862705 in comparison with nondecliners, even after adjustment for confounding variables (OR = 1.84, 95% CI = 1.20-2.82; = 0.0046). No other significant associations were found.
Conclusions: This is the first study showing an association between a variant in a gene belonging to the melatonin system and renal function decline in the diabetic setting.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10972958 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1331012 | DOI Listing |
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