AI Article Synopsis
- This study investigates how genetic factors contribute to degenerative disc disease by reviewing existing literature from 2002 to 2022.
- A total of 84 references were examined, with 43 significant studies selected for detailed analysis after excluding duplicates and less relevant publications.
- Findings indicate that while there is some data on various biological processes involved in the disease, the involvement of genetic regulation remains limited, with certain factors like microRNA and TGF-b needing further research.
Article Abstract
Objective: To analyze available literature data on the role of genetic factors in degenerative disc disease.
Methodology: We reviewed the PubMed, MEDLINE, Cohrane Library, e-Library databases using the following keywords: degenerative spine lesions, intervertebral disc herniation, pathogenesis, genetic regulation.
Results: Searching depth was 2002-2022. We reviewed 84 references. Exclusion criteria: duplicate publications, reviews without detailed description of results, opinions. Finally, we included 43 the most significant studies.
Conclusion: There are literature data on proinflammatory cytokines, growth factors and osteodestructive processes in pathogenesis of degenerative disc disease. However, there is only fragmentary information about the role of genetic regulation of these processes. Some factors, such as microRNA, TGF-b, VEGF, MMP are still poorly understood.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.17116/neiro202488021112 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!