AI Article Synopsis
- Normothermic liver machine perfusion (NLMP) improves the preservation and assessment of liver organs, enhancing their utilization for transplantation, specifically in split liver transplantation (SLT).
- A study analyzed outcomes from adult recipients who underwent SLT after NLMP, measuring 90-day graft and patient survival, as well as post-transplant complications.
- Results showed that NLMP was safe and allowed successful delay of the second split liver graft transplantation, achieving a 100% survival rate at 90 days while documenting some early complications.
Article Abstract
Background: Normothermic liver machine perfusion (NLMP) is advancing the field of liver transplantation (LT). Beyond improved preservation and organ assessment, NLMP helps to increase organ utilization. We herein address the feasibility and merit of NLMP in split liver transplantation (SLT) to postpone the transplantation of the second split graft to the following day.
Methods: We analyzed the perfusion characteristics and outcomes of all consecutive adult recipients who underwent SLT following NLMP from February 1, 2018, to June 30, 2023. The primary endpoint was 90-d graft and patient survival. Secondary endpoints were posttransplant complications and 90-d morbidity.
Results: Three right and 3 extended right SLT following NLMP have been performed. NLMP was uneventful in all cases. Perfusion characteristics differed according to graft volume. Mean perfusion time was 17:00 h (±05:13) and bile production ranged between 8 and 21 mL/h. All split grafts fulfilled predefined center viability criteria during NLMP and were transplanted on the following day. The 90-d graft and patient survival rate was 100%. Three patients (50%) required an early relaparotomy, and 2 patients (33.3%) developed biliary complications. The 90-d morbidity as recorded by the comprehensive complication index was 62.7 (±24.7).
Conclusions: NLMP of split liver grafts is technically feasible and safe. Through prolongation of preservation time, NLMP allows to safely postpone transplantation of the second split liver graft to the next day.
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| http://dx.doi.org/10.1097/TP.0000000000004997 | DOI Listing |
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