AI Article Synopsis
- A study analyzed the microbiota-gut-brain axis in 164 participants, comparing 83 nonagenarians (NAs) with 81 non-nonagenarians (NNAs) and their family members.
- Significant differences in 438 metabolites were found, with NAs showing higher levels of neuroactive compounds and anti-inflammatory substances.
- The results suggest that specific gut microbes and metabolites in NAs are linked to improved brain connectivity and cognitive preservation, highlighting the potential benefits of microbiome balance for longevity and cognitive health.
Article Abstract
The role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrared spectroscopy (fNIRS) in a cohort of 164 participants, including 83 nonagenarians (NAs) and 81 non-nonagenarians (NNAs) matched with their spouses and offspring. We found that 438 metabolites were significantly different between the two groups; among them, neuroactive compounds and anti-inflammatory substances were enriched in NAs. In addition, increased levels of neuroactive metabolites in NAs were significantly associated with NA-enriched species that had three corresponding biosynthetic potentials: , and . Further analysis showed that the altered gut microbes and metabolites were linked to the enhanced brain connectivity in NAs, including the left dorsolateral prefrontal cortex (DLPFC)-left premotor cortex (PMC), left DLPFC-right primary motor area (M1), and right inferior frontal gyrus (IFG)-right M1. Finally, we found that neuroactive metabolites, altered microbe and enhanced brain connectivity contributed to the cognitive preservation in NAs. Our findings provide a comprehensive understanding of the microbiota-gut-brain axis in a long-lived population and insights into the establishment of a microbiome and metabolite homeostasis that can benefit human longevity and cognition by enhancing functional brain connectivity.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984123 | PMC |
| http://dx.doi.org/10.1080/19490976.2024.2331434 | DOI Listing |
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