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Diffusion MRI (dMRI) is inherently limited by SNR. Scanning at 7 T increases intrinsic SNR but 7 T MRI scans suffer from regions of signal dropout, especially in the temporal lobes and cerebellum. We applied dynamic parallel transmit (pTx) to allow whole-brain 7 T dMRI and compared with circularly polarized (CP) pulses in 6 subjects. Subject-specific 2-spoke dynamic pTx pulses were designed offline for 8 slabs covering the brain. We used vendor-provided B and B mapping. Spokes positions were set using the Fourier difference approach, and RF coefficients optimized with a Jacobi-matrix high-flip-angle optimizer. Diffusion data were analyzed with FSL. Comparing whole-brain averages for pTx against CP scans: mean flip angle error improved by 15% for excitation (2-spoke-VERSE 15.7° vs CP 18.4°, P = 0.012) and improved by 14% for refocusing (2-spoke-VERSE 39.7° vs CP 46.2°, P = 0.008). Computed spin-echo signal standard deviation improved by 14% (2-spoke-VERSE 0.185 vs 0.214 CP, P = 0.025). Temporal SNR increased by 5.4% (2-spoke-VERSE 8.47 vs CP 8.04, P = 0.004) especially in the inferior temporal lobes. Diffusion fitting uncertainty decreased by 6.2% for first fibers (2-spoke VERSE 0.0655 vs CP 0.0703, P < 0.001) and 1.3% for second fibers (2-spoke VERSE 0.139 vs CP 0.141, P = 0.01). In conclusion, dynamic parallel transmit improves the uniformity of 7 T diffusion-weighted imaging. In future, less restrictive SAR limits for parallel transmit scans are expected to allow further improvements.
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| http://dx.doi.org/10.1016/j.mri.2024.03.037 | DOI Listing |
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