Expert commentary on the evolving role of proton therapy, discussing the current status and controversies of proton therapy in the modern era.
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http://dx.doi.org/10.1200/OP.24.00132 | DOI Listing |
World J Gastrointest Endosc
January 2025
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Lukang Christian Hospital, Changhua 505002, Taiwan.
Background: Gastric bezoars are indigestible masses that can lead to gastrointestinal obstruction and ulceration. Standard treatments include endoscopic mechanical lithotripsy with a polypectomy snare and Coca-Cola dissolution therapy or a combination of both approaches. However, giant bezoars frequently require multiple treatment sessions and extended hospital stays.
View Article and Find Full Text PDFTech Innov Patient Support Radiat Oncol
March 2025
Cancer Division, University College London Hospitals NHS Foundation Trust, London, UK.
This study investigates whether an Image-Guided Radiation Therapy (IGRT) workbook and Cone Beam Computed Tomography (CBCT) case studies enhances Radiation Therapists' (RTTs) confidence analysing Proton Beam Therapy (PBT) CBCTs. An 11-participant questionnaire-based study was conducted to assess pre- and post-training confidence. Prior to training, RTTs exhibited higher confidence in photon CBCT decision-making over proton CBCT, highlighting the need for PBT-specific IGRT training, irrespective of prior photon experience.
View Article and Find Full Text PDFKorean J Gastroenterol
January 2025
Hanmi Pharmaceutical Co., Ltd., Seoul, Korea.
Background/aims: Gastroesophageal reflux disease (GERD) is a chronic and recurrent condition requiring constant dietary management and medication. This study evaluated the efficacy and safety of HIP1601, a dual delayed-release formulation of esomeprazole, in patients with GERD in a clinical setting.
Methods: This prospective, multicenter, observational study was conducted at 309 medical institutions in Korea between June 2021 and March 2023.
J Immunother Cancer
January 2025
Department of Orthopedic Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA
Background: Chordoma is a slow-growing, primary malignant bone tumor that arises from notochordal tissue in the midline of the axial skeleton. Surgical excision with negative margins is the mainstay of treatment, but high local recurrence rates are reported even with negative margins. High-dose radiation therapy (RT), such as with proton or carbon ions, has been used as an alternative to surgery, but late local failure remains a problem.
View Article and Find Full Text PDFInt J Radiat Oncol Biol Phys
January 2025
National Cancer Institute, Bethesda, MD. Electronic address:
This white paper examines the potential of pioneering technologies and artificial intelligence (AI)-driven solutions in advancing clinical trials involving radiotherapy. As the field of radiotherapy evolves, the integration of cutting-edge approaches such as radiopharmaceutical dosimetry, FLASH radiotherapy, image-guided radiation therapy (IGRT), and AI promises to improve treatment planning, patient care, and outcomes. Additionally, recent advancements in quantum science, linear energy transfer/relative biological effect (LET/RBE), and the combination of radiotherapy and immunotherapy create new avenues for innovation in clinical trials.
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