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CDKN3 as a key regulator of G2M phase in triple-negative breast cancer: Insights from multi-transcriptomic analysis.
IUBMB Life
January 2025
Precision Medicine Laboratory, School of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang, China.
Triple-negative breast cancer (TNBC) remains a significant global health challenge, emphasizing the need for precise identification of patients with specific therapeutic targets and those at high risk of metastasis. This study aimed to identify novel therapeutic targets for personalized treatment of TNBC patients by elucidating their roles in cell cycle regulation. Using weighted gene co-expression network analysis (WGCNA), we identified 83 hub genes by integrating gene expression profiles with clinical pathological grades.
View Article and Find Full Text PDFEarly effects of LT3 + LT4 combination therapy on quality of life in hypothyroid patients: a randomized, double-blind, parallel-group comparison trial.
BMC Endocr Disord
January 2025
Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: This study aimed to evaluate the impact of combined levothyroxine (LT4) and triiodothyronine (LT3) therapy on quality of life in patients with primary hypothyroidism.
Methods: In a randomized, double-blind, parallel-group trial, 151 Iranian patients diagnosed with primary hypothyroidism between 2020 and 2021 were enrolled. One group received LT4 alone (n = 80), while the other received LT4 and LT3 (n = 71) for a minimum of six months.
Colon cancer poses a significant threat to global health, and studies have shown a correlation between physical activity (PA) and the incidence of colon cancer. However, existing research has not quantitatively analyzed PA to evaluate its impact on the risk of colon cancer comprehensively. Data related to the study were obtained from the NHANES database for participants aged 20 and above between 2007 and 2018.
View Article and Find Full Text PDFInfluence of two different printing methods on the accuracy of full-guided implant insertion - a laboratory study in undergraduate dental students.
BDJ Open
January 2025
Department of Oral and Maxillofacial Surgery (Head: Prof. Dr. Dr. Bernd Lethaus), University Hospital Tübingen, Eberhard Karls Universität Tübingen, Osianderstr. 2-8, D-72076, Tübingen, Germany.
Objectives: The aim of the present study was to compare the accuracy of fully guided implant insertion in vitro achieved by two fabrication methods in a cohort of undergraduates. We hypothesized that both methods achieve a comparable accuracy.
Methods: Surface scans and cone beam computed tomography images of 48 mandibular models were matched.
Pain and Physical Function are common core domains across 40 core outcome sets of musculoskeletal conditions: A systematic review.
J Clin Epidemiol
January 2025
Discipline of Physiotherapy, Graduate School of Health, The University of Technology Sydney, New South Wales, Australia.
Objective: To determine common domains across existing musculoskeletal COSs. Secondary aims were to assess the development quality of existing musculoskeletal COSs and whether development quality and patient participation was associated with domain selection.
Study Design And Setting: A systematic review of musculoskeletal COSs.
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