AI Article Synopsis
- Salvage surgery remains the best option for patients with resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC), and transoral robotic surgery (TORS) may minimize recovery issues compared to traditional methods.
- A study of 61 patients showed no major complications, with a 2-year overall survival rate of 76.7% and high rates of patients free from tracheal tubes (97%) and gastrostomy (93%).
- The study concluded that TORS is an effective treatment for selected rOPSCC patients, providing promising oncological and functional results.
Article Abstract
Purpose: Salvage surgery is still the best therapeutic option for resectable recurrent oropharyngeal squamous cell carcinoma (rOPSCC). Transoral robotic surgery may potentially reduce the morbidity of standard open approaches. The aim of the study is to present oncological and functional outcomes of a monocentric experience in salvage transoral robotic surgery.
Methods: We performed a single-center retrospective analysis of patients submitted to transoral robotic salvage surgery with or without neck dissection for cT1-3 rOPSCC. We investigated complication rate, survival outcomes (Overall Survival, Disease Specific Survival, Loco-Regional Recurrence Free Survival) and functional outcomes (tracheal tube and/or gastrostomy dependence).
Results: Sixty-one patients were included in the analysis. No major complications or perioperative deaths were recorded. The estimated 2-year OS was 76.7%, DSS 81.8% and LRRFS 50.5%. In multivariable analysis rpT, PNI (perineural infiltration) and HPV-positivity were significantly associated with LRRFS (Hazard Ratios: T3 vs T1 6.43, PNI yes vs no 4.19, HPV+ yes vs no 2.63). At last follow up, 97% of patients were tracheal tube-free, while 93% were gastrostomy-free.
Conclusion: Transoral robotic salvage surgery is a successful treatment in selected patients affected by rOPSCC because it grants good oncologic and functional outcomes.
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| http://dx.doi.org/10.1007/s00405-024-08590-4 | DOI Listing |
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