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Ethanol extract of Eclipta prostrata induces multiple myeloma ferroptosis via Keap1/Nrf2/HO-1 axis.
Phytomedicine
June 2024
Hangzhou Innovation Institute, Beihang University, Hangzhou, Zhejiang, PR China; Department of Hematology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China. Electronic address:
Background: Multiple myeloma (MM) is an incurable hematological malignancy with limited therapeutic efficacy. Eclipta prostrata is a traditional Chinese medicinal plant reported to possess antitumor properties. However, the effects of E.
View Article and Find Full Text PDFHospital-Based Case-Control Study of MDS Subtypes and Benzene Exposure in Shanghai.
J Occup Environ Med
April 2017
ExxonMobil Biomedical Sciences, Inc. (Drs Copley, Schnatter, Chen); TWA8HR Occupational Hygiene Consulting (Dr Armstrong), New Jersey; Huashan Hospital, Fudan University, China (Drs Irons, Wang, Kerzic); University of Colorado Anshutz Medical Center, Colorado (Dr Irons).
Objective: Due to the sparse data on benzene exposure and myelodysplastic syndrome (MDS) subtypes, we studied this relationship in patients from 29 hospitals in Shanghai, China.
Methods: We recruited 604 cases of MDS and 1193 controls matched on age, sex, and admission date. We interviewed subjects for information on workplace and lifestyle exposures, and developed semi-quantitative exposure estimates.
Is erythroferrone finally the long sought-after systemic erythroid regulator of iron?
World J Biol Chem
August 2015
Alfons Lawen, Department of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Victoria 3800, Australia.
Iron metabolism is regulated on the cellular and the systemic level. Over the last decade, the liver peptide "hepcidin" has emerged as the body's key irons store regulator. The long postulated "erythroid regulator of iron", however, remained elusive.
View Article and Find Full Text PDFIn this issue of , Wang et al describe for the first time a vital link between iron overload and pulmonary hypertension in sickle cell disease (SCD). They report this link is likely placenta growth factor (PlGF).
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