AI Article Synopsis
- African swine fever (ASF) is a severe viral disease affecting domestic pigs, with a very high mortality rate, leading to significant economic losses, particularly in Asia.
- There is an urgent need to create safe and effective vaccines against the African swine fever virus (ASFV), which has a complex genome and encodes around 200 proteins.
- The article reviews vaccine candidates based on ASFV genes/proteins, focusing on structural proteins that have shown protective effects in previous studies.
Article Abstract
African swine fever (ASF) is a highly contagious acute hemorrhagic viral disease, with the mortality rate of up to 100 % in domestic pigs. In recent years, ASF outbreaks have caused huge economic losses in numerous countries and regions, especially in Asia. Therefore, there is a pressing need to develop safe and effective vaccines against infection of the causative pathogen, African swine fever virus (ASFV). ASFV contains a large genome composed of double-stranded DNA with a size of 170-194 kb, which encodes nearly 200 viral proteins. Understanding the function of these complex genes/proteins and their roles in the generation of protective immunity will help in the development of ASFV vaccines. In this article, the gene/protein-based vaccine candidate are summarized, and the structural proteins which have been previously reported to protect animals from the virus challenge were emphatically described.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966157 | PMC |
| http://dx.doi.org/10.1016/j.crmicr.2024.100232 | DOI Listing |
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