AI Article Synopsis
- - The study investigates how Fas-L affects the repair and regeneration of peripheral nerve injuries in rats, specifically looking at its role in neuronal cell apoptosis and axonal regeneration.
- - Results show that Fas-L levels decrease after sciatic nerve injury, and manipulating Fas-L expression can either promote axon regeneration and reduce cell death or inhibit these processes, depending on whether it is increased or decreased.
- - The findings suggest that Fas-L plays a significant role in regulating dorsal root ganglion function and peripheral nerve repair by influencing various signaling pathways, which could provide insights for better approaches in nerve injury treatment.
Article Abstract
Objective: To investigate the regulatory effect of Fas-L on the repair and regeneration of peripheral extension injury in rats.
Methods: This study aimed to explore the effects of Fas-L on apoptosis and axonal regeneration of dorsal root ganglion (DRG) cells in rat peripheral nerve repair and regeneration by using several relevant experimental techniques from the injured nerve animal model, cell biology, and molecular biology.
Results: The expression level of Fas-L in DRG tissues was significantly down-regulated after sciatic nerve injury. Interference with Fas-L can significantly promote the regeneration of DRG neuronal axons and inhibit apoptosis, while the overexpression of Fas-L is contrary to it. Moreover, Fas-L may play a role in the regulation of DRG function and the repair and regeneration of peripheral nerves in Sprague Dawley (SD) rats by affecting several signaling pathways, such as p-AKT/AKT, β-catenin, and NF-κB.
Conclusion: Fas-L may have a certain effect on the repair and regeneration of peripheral nerve injury in SD rats, which may provide an experimental basis and a new theoretical basis for the functional reconstruction of peripheral nerves.
Significance Statement: The expression level of Fas-L in DRG tissues was significantly down-regulated after sciatic nerve injury. Fas-L can significantly promote the regeneration of DRG neuronal axons and inhibit apoptosis. Fas-L may play a role in the regulation of DRG function and the repair and regeneration of peripheral nerves in SD rats by affecting several signaling pathways, such as p-AKT/AKT, β-catenin, and NF-κB. Fas-L may have a certain effect on the repair and regeneration of peripheral nerve injury in SD rats, which may provide an experimental basis and a new theoretical basis for the functional reconstruction of peripheral nerves.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10966190 | PMC |
| http://dx.doi.org/10.1016/j.ibneur.2024.02.008 | DOI Listing |
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