In this paper we propose the method for detecting potential anomalous cosmic ray particle tracks in big data image dataset acquired by Complementary Metal-Oxide-Semiconductors (CMOS). Those sensors are part of scientific infrastructure of Cosmic Ray Extremely Distributed Observatory (CREDO). The use of Incremental PCA (Principal Components Analysis) allowed approximation of loadings which might be updated at runtime. Incremental PCA with Sequential Karhunen-Loeve Transform results with almost identical embedding as basic PCA. Depending on image preprocessing method the weighted distance between coordinate frame and its approximation was at the level from 0.01 to 0.02 radian for batches with size of 10,000 images. This significantly reduces the necessary calculations in terms of memory complexity so that our method can be used for big data. The use of intuitive parameters of the potential anomalies detection algorithm based on object density in embedding space makes our method intuitive to use. The sets of anomalies returned by our proposed algorithm do not contain any typical morphologies of particle tracks shapes. Thus, one can conclude that our proposed method effectively filter-off typical (in terms of analysis of variance) shapes of particle tracks by searching for those that can be treated as significantly different from the others in the dataset. We also proposed method that can be used to find similar objects, which gives it the potential, for example, to be used in minimal distance-based classification and CREDO image database querying. The proposed algorithm was tested on more than half a million (570,000+) images that contains various morphologies of cosmic particle tracks. To our knowledge, this is the first study of this kind based on data collected using a distributed network of CMOS sensors embedded in the cell phones of participants collaborating within the citizen science paradigm.
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http://dx.doi.org/10.3390/s24061835 | DOI Listing |
Int J Parasitol
January 2025
Institute of Parasitology, Department for Biological Sciences and Pathobiology, University of Veterinary Medicine Vienna, Veterinärplatz 1 A-1210 Vienna, Austria.
Cystoisospora suis, a porcine enteral parasite of the order Coccidia, is characterized by a complex life cycle, with asexual and sexual development in the epithelium of the host gut and an environmental phase as an oocyst. All developmental stages vary greatly in their morphology and function, and therefore excrete different bioactive molecules for intercellular communication. Due to their complex development, we hypothesized that the extracellular vesicles (EVs) cargo is highly dependent on the life cycle stages from which they are released.
View Article and Find Full Text PDFJ Pharm Sci
January 2025
Department of Process and Life Science Engineering, Div. Food and Pharma, Lund University, P.O. Box 124, 22100 Lund, Sweden.
In hospitals, IV bags can be prepared in advance for logistical and microbial safety reasons in a compounding unit and then transported to wards. Transport of protein drugs using a pneumatic tube system has been reported to result in high particle levels. In this study, pneumatic tube transport of trastuzumab in saline polyolefin bags was compared to delivery by hospital porters using an electric platform truck in an underground tunnel system.
View Article and Find Full Text PDFNanoscale Adv
January 2025
Department of Modern Mechanical Engineering, Waseda University 3-4-1 Ookubo Shinhuku-ku Tokyo Japan
The diffusion motions of individual polymer aggregates in disordered porous media were visualized using the single-particle tracking (SPT) method because the motions inside porous media play important roles in various fields of science and engineering. In the aggregates diffused on the surfaces of pores, continuous adsorption and desorption processes were observed. The relationship between the size of the aggregates and pore size was analysed based on diffusion coefficients, moment scaling spectrum (MSS) slope analysis, and diffusion anisotropy analysis.
View Article and Find Full Text PDFJ Extracell Biol
January 2025
RoseBio Milano Italy.
Current state-of-the-art tools for analysing extracellular vesicles (EVs) offer either highly sensitive but unidimensional bulk measurements of EV components, or high-resolution multiparametric single-particle analyses which lack standardization and appropriate reference materials. This limits the accuracy of the assessment of marker abundance and overall marker distribution amongst individual EVs, and finally, the understanding of true EV heterogeneity. In this study, we aimed to define the standardized operating procedures and reference material for fluorescent characterization of EVs with two commonly used EV analytical platforms-nanoparticle tracking analysis (NTA) and nano-flow cytometry (nFCM).
View Article and Find Full Text PDFSci Rep
January 2025
Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge, CB3 0FS, UK.
Shells of Pd and Pt were synthesized on Au nanoparticles by electrodeposition, leading to controllable size and optical properties. This approach yielded core-shell structures with good homogeneity in size after the optimization of electrochemical parameters such as deposition current and charge transfer, as well as nanoparticle surface treatment. Dark field scattering microscopy and spectroscopy were used to track changes in the optical response of individual particles during deposition.
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