AI Article Synopsis
- - COVID-19 is a serious and contagious respiratory illness, leading to the search for new treatments, particularly looking into polysaccharides with antiviral potential.
- - The study focused on the antiviral effects of the drug "Immeran" against SARS-CoV-2 in hamsters, testing doses of 500 and 1000 μg/kg through intraperitoneal injections.
- - Results showed that Immeran effectively reduced virus replication in the lungs and, at the higher dose, prevented weight loss in hamsters, while also promoting the production of anti-SARS-CoV-2 antibodies, indicating it might enhance immune responses.
Article Abstract
COVID-19 is a highly contagious respiratory disease with a high number of lethal cases in humans, which causes the need to search for new therapeutic agents. Polysaccharides could be one of the prospective types of molecules with a large variety of biological activities, especially antiviral. The aim of this work was to study the specific antiviral activity of the drug "Immeran" on a model of a new coronavirus infection SARS-CoV-2 in hamsters. Based on the second experiment, intraperitoneal treatment with the drug according to a treatment regimen in doses of 500 and 1000 μg/kg (administration after an hour, then once a day every other day, a total of 3 administrations) was effective, reliably suppressing the replication of the virus in the lungs and, at a dose of 1000 μg/kg, prevented weight loss in animals. In all cases, the treatment stimulated the formation of virus-neutralizing antibodies to the SARS-CoV-2 virus, which suggests that the drug possesses adjuvant properties.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976179 | PMC |
| http://dx.doi.org/10.3390/v16030423 | DOI Listing |
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