has recently been reported as a rare cause of prosthetic joint infections (PJIs), contrary to , which is well established as a cause of PJIs, especially in shoulder arthroplasties. Two specific risk factors for PJI due to have been reported: obesity and the skin incision approach. Here, we report four cases of hip PJIs caused by admitted over a 30-month period at a single center. Whole-genome sequencing revealed that the four strains were all individual strains and did not originate from a common source, such as an outbreak. Antibiotic susceptibility tests showed that the isolates were fully susceptible, and none carried known antibiotic resistance genes. In conclusion, the occurrence of four cases of PJI caused by over a limited time at a single center may indicate that this pathogen is underestimated and is either emerging or more common than previously recognized. The patients presented overt signs of infection during surgery, indicating that is a virulent pathogen. None of the previously reported risk factors for PJI applied to these patients as only one was obese and none were operated on using a direct anterior skin incision approach.
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http://dx.doi.org/10.3390/microorganisms12030432 | DOI Listing |
Cells
February 2025
Departmental Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy.
Human immunodeficiency virus (HIV) infection continues to be a major global health challenge, affecting 38.4 million according to the Joint United Nations Program on HIV/AIDS (UNAIDS) at the end of 2021 with 1.5 million new infections.
View Article and Find Full Text PDFPurpose: Total knee arthroplasty (TKA) in patients who underwent previous knee surgeries can be a challenging procedure both technically and for the complication rate. Conversion TKA is affected by a higher risk of infection compared to primary TKA. The aims of this meta-analysis are i) to compare the infectious risk among patients undergoing TKA after a prior hardware implantation, evaluating removal vs maintenance of the hardware, and ii) within the removal group, to compare staged vs concurrent procedure.
View Article and Find Full Text PDFJ Virol
March 2025
College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Unlabelled: Porcine reproductive and respiratory syndrome virus (PRRSV) isolates share a restricted cellular tropism. Marc-145 cells derived from African green monkey are one of the few cell lines supporting PRRSV propagation and are commonly used for PRRS vaccine development. However, currently prevalent PRRSV isolates display different Marc-145 cell tropism while the exact determinant is not clarified yet.
View Article and Find Full Text PDFThe diagnosis, risk factors, treatment algorithms, and long-term sequelae of superficial and deep, implant-related infections in transdermal, bone-anchored osseointegration are not well-defined. In contrast to the robust experience diagnosing and managing periprosthetic joint infections in total joint arthroplasty, osseointegration surgery has only recently been adopted at a small number of osseointegration centers in the United States, contributing to the lack of long-term outcomes. Through the pooled experience from these osseointegration centers, we present a consensus statement on the perioperative management, incidence, treatment, and diagnostic workup for infectious complications following transdermal, bone-anchored osseointegration.
View Article and Find Full Text PDFOTA Int
March 2025
Atrium Health-Carolinas Medical Center, Atrium Health Musculoskeletal Institute, Charlotte, NC.
Purpose: Osseointegration-associated infections are a critical barrier to widespread implementation of osseointegrated (OI) prosthetics. To address this challenge, a preclinical animal model must exist of the human model to test potential interventions. In this article, we describe a novel rabbit model of OI implant-related infection that can act as a platform for rapid translation and development of therapeutic approaches to combat these uniquely challenging infections.
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