AI Article Synopsis
- The study aimed to evaluate how effective and safe vaccinations are for patients with follicular lymphoma (FL), while also considering the potential for developing new immunotherapies.
- Researchers analyzed randomized clinical trials involving therapeutic vaccines and measured progression-free survival (PFS) as the main outcome, using various databases and assessment tools to ensure robust results.
- The findings indicated that patients receiving the Id-KLH vaccine showed little to no significant difference in PFS compared to those receiving a placebo, with moderate certainty in the evidence, and the adverse effects reported were mixed.
Article Abstract
(1) Background: We aimed to estimate the pooled effectiveness and safety of vaccination in follicular lymphoma (FL) and discuss implications for immunotherapy development. (2) Methods: We included randomized trials (RCTs) of therapeutic vaccines in patients with FL. Progression-free survival (PFS) was the primary outcome. We searched databases (PubMed, Embase, Scopus, Web of Science Core, medRxiv) and registries (PROSPERO, CENTRAL, ClinicalTrials.gov, EuCTR, WHO ICTRP) and conducted online, citation, and manual searches. We assessed risks of bias across outcomes using RoB 2.0 and across studies using ROB-ME and a contour-enhanced funnel plot. (3) Results: Three RCTs were included (813 patients, both previously treated and untreated). Patients with a complete or partial response after chemotherapy were randomized to either a patient-specific recombinant idiotype keyhole limpet hemocyanin (Id-KLH) vaccine plus granulocyte-macrophage colony-stimulating factor (GM-CSF) or placebo immunotherapy (KLH + GM-CSF). Meta-analyses showed that PFS was worse with the vaccine, but not significantly: hazard ratio, 1.09 (95% CI 0.91-1.30). The GRADE certainty of evidence was moderate. Adverse event data were mixed. (4) Conclusions: We are moderately certain that Id-KLH results in little to no difference in PFS in FL. (5) Funding: Russian Science Foundation grant #22-25-00516. (6) Registration: PROSPERO CRD42023457528.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10974604 | PMC |
| http://dx.doi.org/10.3390/ph17030272 | DOI Listing |
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